Results 51 to 60 of about 6,712 (268)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Estructura y diversidad arbórea en dos corredores de bosque de galería en la Orinoquia colombiana

Biota Colombiana
Este estudio compara la estructura y diversidad de árboles en dos corredores de bosque de galería en la altillanura de la Orinoquia colombiana, en Puerto Gaitán, Meta.
Ronny Miguel Quimbayo Garzón, Marcia Carolina Muñoz Neyra   +1 more
doaj   +1 more source

Spatial predictions of tree density and tree height across Mexico forests using ensemble learning and forest inventory data

Ecology and Evolution, 2023
The National Forestry Commission of Mexico continuously monitors forest structure within the country's continental territory by the implementation of the National Forest and Soils Inventory (INFyS).
Aylin Barreras, José Armando Alanís de la Rosa, Rafael Mayorga, Rubi Cuenca, César Moreno‐G, Carlos Godínez, Carina Delgado, Maria de los Ángeles Soriano‐Luna, Stephanie George, Metzli Ileana Aldrete‐Leal, Sandra Medina, Johny Romero, Sergio Villela, Andrew Lister, Rachel Sheridan, Rafael Flores, Thomas W. Crowther, Mario Guevara   +17 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Extensionismo Forestal

Revista Mexicana de Ciencias Forestales, 2017
La generación de conocimientos, además de cumplir la función de responder a las interrogantes que el entorno le plantea al hombre, debe de reflejarse en el desarrollo de tecnologías que contribuyan a mejorar su calidad de vida, le den seguridad ...
Marisela Cristina Zamora Martínez
doaj  

Forest Packing: Fast Parallel, Decision Forests [PDF]

, 2019
Machine learning has an emerging critical role in high-performance computing to modulate simulations, extract knowledge from massive data, and replace numerical models with efficient approximations. Decision forests are a critical tool because they provide insight into model operation that is critical to interpreting learned results.
James Browne, Disa Mhembere, Tyler M. Tomita, Joshua T. Vogelstein, Randal C. Burns   +4 more
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Segona Reunió sobre Història Forestal Valladolid, 18-20 de setembre del 2003

Documents d'Anàlisi Geogràfica, 2004
Del 18 al 20 de setembre del 2003 es va celebrar a Valladolid la Segona Reunió sobre Història Forestal, convocada pel Grup de Treball d’Història Forestal de la Societat Espanyola de Ciències Forestals (SECF).
Albert Pèlachs Mañosa, Joan Manuel Soriano López   +1 more
doaj   +1 more source