Results 231 to 240 of about 958,943 (309)

Multi‐Scale Mapping of Gene Expression from Whole‐slide Images for Identifying Phenotype‐Associated Subpopulations

open access: yesAdvanced Science, EarlyView.
BiSCALE: A pathology‐driven deep learning framework for multi‐scale gene expression prediction from whole‐slide images. It accurately infers bulk and near‐cellular spot‐level expression, links predictions to clinical phenotypes, identifies disease‐associated niches, and enables applications in risk stratification and cell‐identity annotation, providing
Hailong Zheng   +8 more
wiley   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

open access: yesAdvanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu   +15 more
wiley   +1 more source

Subsidies to forestry [PDF]

open access: yes
Tolonen, Yrjänä
core  

Hierarchical Channeled Graphitized Nanoarchitecture as a Diagnostic Platform for Maternal Fever Warning

open access: yesAdvanced Science, EarlyView.
This study presents a hierarchically channeled graphitized nanoarchitecture (HPGC‐Z67) as a novel nano‐diagnostic platform. It enables sensitive and efficient N‐glycan extraction from plasma, significantly reducing processing time and cost. The platform identifies pivotal N‐glycans to accurately differentiate between infectious and non‐infectious ...
Yiwen Lin   +5 more
wiley   +1 more source

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

open access: yesAdvanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li   +8 more
wiley   +1 more source

A multi-omics dissection of the molecular mechanisms underlying water soaking in fresh-cut watermelon. [PDF]

open access: yesMol Hortic
Liu X   +11 more
europepmc   +1 more source

An Integrated NLP‐ML Framework for Property Prediction and Design of Steels

open access: yesAdvanced Science, EarlyView.
This study presents a data‐driven framework that uses language‐processing techniques to interpret steel processing descriptions and machine‐learning models to predict mechanical properties. By organising complex process histories into meaningful groups and enabling rapid property forecasts, the work supports faster, more informed steel design through ...
Kiran Devraju   +5 more
wiley   +1 more source

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