Results 121 to 130 of about 34,335,892 (348)

Optimization and Evaluation of Cannabis-Based Magistral Formulations: A Path to Personalized Therapy

Pharmaceuticals
Introduction: The official implementation of pharmaceutical-grade cannabis raw materials for medicinal use has permitted doctors to prescribe and pharmacists to prepare cannabis-based formulations.
Bożena Grimling, Magdalena Fast, Magdalena Okoniewska, Artur Owczarek, Bożena Karolewicz   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Machine Learning-Based Recommender System for Pulsed Laser Ablation in Liquid: Recommendation of Optimal Processing Parameters for Targeted Nanoparticle Size and Concentration Using Cosine Similarity and KNN Models

Crystals
Achieving targeted nanoparticle (NP) size and concentration combinations in Pulsed Laser Ablation in Liquid (PLAL) remains a challenge due to the highly nonlinear relationships between laser processing parameters and NP properties. Despite the promise of
Anesu Nyabadza, Dermot Brabazon
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Point-form quantum field theory and meson form factors

, 2007
We shortly review point-form quantum field theory, i.e. the canonical quantization of a relativistic field theory on a Lorentz-invariant surface of the form $x_\mu x^\mu = \tau^2$.
B Bakamjian, CJ Bebek, CM Sommerfield, D Gromes, E. P. Biernat, EP Biernat, K. Fuchsberger, W. H. Klink, W. Schweiger, WH Klink   +9 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Assessing subvisible particle risks in monoclonal antibodies: insights from quartz crystal microbalance with dissipation, machine learning, and in silico analysis

mAbs
Throughout the lifecycle of biopharmaceutical development and manufacturing, monoclonal antibodies (mAbs) are subjected to diverse interfacial stresses and encounter various container surfaces.
Yibo Wang, Alexis Hanford, Mehdi Boroumand, Cavan Kalonia, Jesse Leissa, Mitali Shah, Tony Pham, Theodore Randolph, Indira Prajapati   +8 more
doaj   +1 more source

Inner products and Z/p-actions on Poincaré duality spaces [PDF]

, 2003
Alexander J. P., Alexander J. P., Bernhard Hanke, Bredon G. E., Chang T., Eilenberg S., Hanke B., Hanke B., Jones L., Milnor J., Serre J. P.   +10 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source