Comparative analysis of <i>Asterias forbesi</i> development reveals distinct mechanisms of hydro-vascular organ formation across sea stars. [PDF]
Discov Dev BiolMarc TK, Rodger A, Perillo M.
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Generation of multi-form exact wave solutions and linear stability analysis in the generalized (3+1)-D P-type plasma system using a modified extended mapping technique. [PDF]
Sci RepGhayad MS, Ahmed HM, Badra NM, Rabie WB.
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Fatal Myocarditis Caused by Canine Parvovirus in a Litter of One-Day-Old German Shepherd Puppies: Molecular and Histopathological Findings. [PDF]
Vet Med SciJarolmasjed S +5 more
europepmc +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Exploratory observational study of the association between bacterial L-form detection and intrauterine infection in pregnant women with placenta previa and bleeding. [PDF]
Front Med (Lausanne)Jiang S, Li X, Wei Y, Zheng X.
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Shortening the SWAL-QOL: Is it possible to create a valid short form? [PDF]
Parkinsonism Relat DisordSevitz JS, Harel D, Troche MS.
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source