Results 201 to 210 of about 6,364,465 (258)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
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Forms of meaning, meaning of forms
Journal of Experimental & Theoretical Artificial Intelligence, 2002If work in psychology has clearly brought to light that ‘conceptual flexibility’ exists in the categorization of objects, which led to re-questioning the traditional conception of categorization which considers rigid and discontinuous categories, it is not the case in linguistics and psycholinguistics.
Bruno Gaume +3 more
openaire +2 more sources
Clinical Diabetes, 2013
W ith all the challenges of modern health care practices, the proliferation of certification for medical necessity (CMN) forms and other documentation requirements has become an increasing distraction from conversing with, examining, and critically thinking about patients.
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W ith all the challenges of modern health care practices, the proliferation of certification for medical necessity (CMN) forms and other documentation requirements has become an increasing distraction from conversing with, examining, and critically thinking about patients.
openaire +1 more source
Introduction: Form, Forms, and Forming
2016The central methodology that poetry is the investigation of complex contemporary realities through the means and meanings of form is introduced, via accounts of other ‘turns’ in recent literary studies (the importance of poetics is also underlined), leading to a reading of formalist criticism in the works of Derek Attridge, Susan Wolfson, Peter de Bola,
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Evaluating Evaluation Forms Form
Obstetrics & Gynecology, 2004To provide a tool for evaluating evaluation forms.A new form has been developed and tested on itself and a sample of evaluation forms obtained from the graduate medical education offices of several local universities. Additional forms from hospital administration were also subjected to analysis.The new form performed well when applied to itself.
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Abstract Chapter Thirteen investigates syndicated leveraged loans that fall along the continuum between one-off bespoke contracts and public bonds. These instruments are tradable, albeit the markets for them are not as thick as those for public bonds.
Stephen J Choi +2 more
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Stephen J Choi +2 more
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