Results 51 to 60 of about 555,638 (313)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Practical challenges in data‐driven interpolation: Dealing with noise, enforcing stability, and computing realizations

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley   +1 more source

Design of an LCC current-output resonant converter for use as a constant current source [PDF]

, 2007
A methodology for the design of LCC resonant current-source converters, is presented. Unlike previous techniques, the resulting converter provides near constant steady-state output current over an extended load range when excited at the resonant ...
Bingham, Chris, Foster, M. P., Gilbert, A .J., Stone, D. A.   +3 more
core   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri, Mauro Gaggero, Marcello Sanguineti   +2 more
wiley   +1 more source

Research on Trimming Frequency-Increasing Technology for Quartz Crystal Resonator Using Laser Etching

Micromachines, 2021
A quartz crystal resonator (QCR) is an indispensable electronic component in the field of the modern electronics industry. By designing and depositing electrodes of different shapes and thicknesses on a quartz wafer with a certain fundamental frequency ...
Jun-Lin Zhang, Shuang Liao, Cheng Chen, Xiu-Tao Yang, Sheng-Ao Lin, Feng Tan, Bing Li, Wen-Wu Wang, Zheng-Xiang Zhong, Guang-Gen Zeng   +9 more
doaj   +1 more source

Global production networks in the aerospace industry: the role of risk and revenue sharing partnerships [PDF]

, 2012
The last 30 years have seen a major trend towards the internationalisation of production. In some industry sectors this process has become global as production systems have been integrated on an inter-continental basis.
Smith, DJ, Williams, DA
core  

Double-logarithmic asymptotics of the electromagnetic form factors of the electron and quark [PDF]

Nuclear Physics B, 2000
The asymptotic behaviour of the electromagnetic form factors of the electron and quark is obtained in the double-logarithmic approximation for Sudakov kinematics, i.e. for the case that the value of the momentum transfer is much greater than the mass of the particle.
B. I. Ermolaev, S. I. Troyan
openaire   +4 more sources

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

Form factor ratio from unpolarized elastic electron-proton scattering [PDF]

Physical Review C, 2016
A reanalysis of unpolarized electron-proton elastic scattering data is done in terms of the electric to magnetic form factor squared ratio. This observable is in principle more robust against experimental correlations and global normalizations.
Pacetti, Simone, Tomasi-Gustafsson, Egle
openaire   +3 more sources