Results 201 to 210 of about 25,005,250 (309)

The Animal Variant Classification Guidelines v2: An Update With New Criteria and Improved Clarifications. [PDF]

Anim Genet
Desmet L, Ferrari C, Abitbol M, Anderson H, Bannasch D, Bauer H, Bell J, Bilgen N, Chevallier L, Dufaure de Citres C, Donner J, Finno CJ, Giovambattista G, Harrison SM, Hayward JJ, Häggström J, Huff JT, Leeb T, Ljungvall I, Longeri M, Lyons LA, Martinez M, Mellersh C, Nicholas FW, Ohlsson Å, Petersen JL, Smets P, Strillacci MG, Tammen I, Van Buren S, van Steenbeek FG, Broeckx BJG.   +31 more
europepmc   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

From benchmarking to global leadership: Singapore's health sciences authority's journey to WHO maturity level 4 and WHO-Listed Authority status for medicines. [PDF]

Front Med (Lausanne)
Toh D, Lim A, Chan A, Chia A, Ang PS, Tan A, Foo B, Chan B, Chong L, Choo Q, Choong CT, Ho C, Chua SW, Chuah SC, Rodrigues CL, Chuah D, Sun D, Koh D, Yeo D, Tan E, Goh E, Lee E, Ee F, Foo F, Ge XW, Goh CH, Han PY, Poh J, Low J, Teo J, Ng J, Lai WF, Lee HK, Lim BK, Lim LL, Lim N, Lin S, Ling BL, Tan L, Looi YH, Low MY, Limenta M, Ng LT, Ong SY, Peck LF, Soh S, Seng TJ, Shinta, Sachidanandan S, Soh XW, Tan SK, Tang X, Tham MY, Toh T, Gan V, Lai V, Xu Y, Yang S, Yeo W, Yip YY, Chan CL.   +60 more
europepmc   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi, Sola Al Ghazal, Salem Hannoun, Medhat A. Siddik, Nour M. Najjar, Jim Dagher, Joseph Abboud, Myriam G. Semaan, Samia J. Khoury   +8 more
wiley   +1 more source

Perioperative antithrombotic management in degenerative spine surgery: a multicenter cohort of 767 consecutive patients. [PDF]

Front Med (Lausanne)
Corazzelli G, Corvino S, Rios DL, Gentile D, Di Domenico C, Corazzelli F, De Rosa G, Fiore F, Germano C, Filippelli M, Colella N, Ricciardi F, D'Elia A, Leonetti S, Sacco M, Meglio V, Pizzuti V, Di Russo P, Gorgoglione N, Petrella G, Mastantuoni C, Scala MR, de Angelis M, De Bellis A, Cioffi V, Aloj F, Sigona L, Bocchetti A, Di Colandrea S, Coscia G, Passavanti MB, Cuomo A, De Marinis P, Tocchetti CG, de Divitiis O, Mormile M, Cirillo P, Catapano G, de Falco R, Paolini S, Esposito V, Innocenzi G.   +41 more
europepmc   +1 more source

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

Case Report: Pediatric immune-mediated necrotizing myopathies mimicking inherited muscle disorders: clinical, paraclinical, and genetic insights from two cases. [PDF]

Front Pediatr
Severa G, Cortes-Rojas MC, Gomez-Garcia de la Banda M, Belmondo T, Benezit A, Leturcq F, Verebi C, Periou B, Gallardo E, Cassandrini D, Gendre T, Hue S, Gitiaux C, Toubal N, Nouioua S, Boucher N, Bader-Meunier B, Authier FJ, Carlier RY, Quijano-Roy S, Malfatti E.   +20 more
europepmc   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Early adverse events and patient-reported outcomes after salvage radiotherapy following prostatectomy according to fractionation schedule: Interim analysis of the phase III URONCOR 06-24 trial. [PDF]

Clin Transl Radiat Oncol
Couñago F, González C, Gómez-Iturriaga A, Álvarez A, Santos M, Boladeras A, García N, Fernández S, Guardado S, Ocanto A, Gonsalves D, Glaría L, Castaño A, Martín P, Montezuma L, Mera A, Mases J, Meca G, Duque-Santana V, Olivera J, Pérez S, Henriquez I, Malavé B, Rodríguez A, García R, Büchser D, Garre J, Altabas M, Valero J, García-Gómez R, Berenguer M, Calvo Á, Ordoñez R, Willisch P, Candal A, Aymar N, Mayrata E, López-Campos F.   +37 more
europepmc   +1 more source