Results 151 to 160 of about 852,128 (332)

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

open access: yesAdvanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang   +5 more
wiley   +1 more source

On Formal Analysis of OO Languages using Rewriting Logic: Designing for Performance [PDF]

open access: yes, 2007
A. Farzan   +14 more
core   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

open access: yesAdvanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang   +8 more
wiley   +1 more source

Language concordance in the digital collection of patient-reported outcome measures. [PDF]

open access: yesJAMIA Open
Liu JB   +7 more
europepmc   +1 more source

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

open access: yesAdvanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang   +11 more
wiley   +1 more source

Convergent and Divergent Connectivity Patterns of the Arcuate Fasciculus in Macaques and Humans

open access: yesAdvanced Science, EarlyView.
This study employs viral‐based single‐neuron tracing and dMRI‐based whole‐brain tractography to investigate arcuate fasciculus (AF) trajectories in macaque monkeys, and compares with the human AF connectome using spectral embedding. Results demonstrate conserved AF topography spanning temporoparietal‐auditory‐frontal pathways across primates, with ...
Jiahao Huang   +17 more
wiley   +1 more source

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