Results 181 to 190 of about 14,914,060 (244)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

PRISMA 2020 Is a Reporting Guideline for Systematic Reviews but Is Often Misused to Guide Review Content. [PDF]

Cochrane Evid Synth Methods
Østengaard L, Korfitsen CB, Hróbjartsson A, Laursen DRT, Nejstgaard CH.   +4 more
europepmc   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Student Competency in Outpatient Documentation: Insights From the 2025 CERA Clerkship Directors Study. [PDF]

Fam Med
Dabbs W, Sairenji T, Farah S, Heidel E, Nikbakht A, Heidelbaugh JJ, Chamberlin S.   +6 more
europepmc   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Formal Methods, 2-6 November

The Reasoner, 2009
Ana Cavalcanti, Dennis Dams
doaj  

Patient and Family Perspectives on Statutory Duty of Candour Following Serious Adverse Patient Safety Events. [PDF]

Health Expect
Adams C, Bowditch L, Bierbaum M, Walsan R, Morris J, Manias E, Youngs N, Birks L, Braithwaite J, Chauhan A, Hibbert P, Walpola R, Harrison R.   +12 more
europepmc   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Correction to: Making Sense of Projects—Developing Project Portfolio Management Capabilities

Schmalenbach Journal of Business Research
Frederik Ahlemann, Peder Bergan, Erik Karger, Malte Greulich, Stefan Reining   +4 more
doaj   +1 more source

Strengthening capacity for pandemic preparedness among health care professionals through interdisciplinary online learning: a participatory mixed-methods evaluation. [PDF]

Front Public Health
Ibeto M, Tahir IM, Danmallam M, Kamau B, Mtaki V, Zulu PM, Tusabe F, Wangai H, Waya C, Clery E, Fide-Nwaogu C, Wild J, Haque F, Nzegwu F.   +13 more
europepmc   +1 more source