Results 211 to 220 of about 81,395 (299)

Overexpression of mitofusin 2 ameliorates inflammation and oxidative stress in lipopolysaccharide‐induced mastitis model by regulating phosphofurin acidic cluster sorting protein 2

Animal Models and Experimental Medicine, EarlyView.
The interaction between mitofusin 2 (MFN2) and phosphofurin acidic cluster sorting protein 2 regulates the formation of mitochondria‐associated endoplasmic reticulum membranes (MAM). Overexpression of MFN2 can promote the formation of MAMs and inhibit inflammation and oxidative stress response in mammary epithelial cells.
Xiechen Zhou, Yufei Zhang, He Ma, Shoupeng Fu, Juxiong Liu, Wenjin Guo, Xiaofeng Tian, Bingxu Huang   +7 more
wiley   +1 more source

SquiDBase: a community resource of raw nanopore data from microbes. [PDF]

NAR Genom Bioinform
Cuypers WL, Ceylan H, Turcksin E, Raes L, de Vrij N, Michiels J, Coppens S, de Block T, Jansen D, Ariën KK, Selhorst P, Vercauteren K, Gauglitz JM, Bittremieux W, Laukens K.   +14 more
europepmc   +1 more source

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

Animal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai, Xintao Zhang, Tingting Luo, Wenhan Chen, Chenyu Ma, Haihua Luo, Jinghua Liu, Jia Xu   +7 more
wiley   +1 more source

Building a framework for reproducibility: the case for standardized data reporting and metadata integration in zebrafish research.

Dis Model Mech
Ngu MS, Toro S, Burger A, Ang KC.
europepmc   +1 more source

Medicines, Diseases, Indications, and Contraindications (MeDIC): a foundational resource to support drug repurposing. [PDF]

Nucleic Acids Res
DeLuca M, Matentzoglu N, Sharp E, Li J, Hempstead C, Lim M, Kaniewski P, Carter EK, Koirala K, Ding E, Vijnck L, Brokmeier P, Toro S, Schaper K, Vergine J, Li O, Oprea TI, Fajgenbaum DC, Bizon C, Haendel M, Tropsha A.   +20 more
europepmc   +1 more source

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

PF-AGCN: an adaptive graph convolutional network for protein-protein interaction-based function prediction. [PDF]

Bioinformatics
Yang S, Su Y, Lin Y, Lin Q, Chen Z.
europepmc   +1 more source

TARDBP (TDP‐43) Knock‐in Zebrafish Display a Late‐Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons

Annals of Neurology, EarlyView.
Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji, Christian J. Rampal, Esteban C. Rodríguez, Virginie Petel Légaré, Alexandra Lissouba, Sabrina Semmler, Meijiang Liao, Jay P. Ross, Guy A. Rouleau, Christine Vande Velde, Gary A.B. Armstrong   +10 more
wiley   +1 more source