Results 41 to 50 of about 81,395 (299)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Formal Ontologies and Coherent Spaces
Journal of Applied Logic, 2014 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
ABRUSCI, Vito Michele +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
СибСкриптNatural language processing methods can be used to predict advanced application trends in formal ontologies. Formal ontologies help to formalize the characteristics of objects in various domains.
M. M. Charnine, S. S. Kalinin
doaj +1 more source
Conceptual Models for Intangible Art
Mimesis Journal, 2014 Formal ontologies have been fruitfully employed to describe and document cultural heritage with the twofold goals of providing explicit and shared conceptual models of cultural heritage and of making documentation directly available to men and machines ...
Antonio Lieto +2 more
doaj +1 more source
The Knowledge of the Grid: A Grid Ontology [PDF]
, 2006 This paper presents a knowledge architecture and set of ontologies that can be used as the foundation to facilitate the matching of abstract resource requests to services and resources, to determine the functional equivalence of Grid middle wares and ...
Brooke, J. +4 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Methods for Domain Specification of Verification-Oriented Process Ontology
Моделирование и анализ информационных систем, 2019 User-friendly formal specifications and verification of parallel and distributed systems from various subject fields, such as automatic control, telecommunications, business processes, are active research topics due to its practical significance. In this
Natalia O. Garanina +3 more
doaj +1 more source
On the proper treatment of pathologies in biomedical ontologies [PDF]
, 2005 In previous work on biomedical ontologies we showed how the provision of formal definitions for relations such as is_a and part_of can support new types of auto-mated reasoning about biomedical phenomena.
Kumar, Anand, Smith, Barry
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source