Results 51 to 60 of about 81,395 (299)

Towards ontology interoperability through conceptual groundings [PDF]

, 2008
. The widespread use of ontologies raises the need to resolve heterogeneities between distinct conceptualisations in order to support interoperability.
Dietze, Stefan, Domingue, John
core   +2 more sources

Relations in biomedical ontologies [PDF]

, 2005
To enhance the treatment of relations in biomedical ontologies we advance a methodology for providing consistent and unambiguous formal definitions of the relational expressions used in such ontologies in a way designed to assist developers and users in ...
Ceusters, Werner, Klagges, Bert, Kumar, Anand, Köhler, Jacob, Lomax, Jane, Mungall, Chris, Neuhaus, Fabian, Rector, Alan L, Rosse, Cornelius, Smith, Barry   +9 more
core   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Logical–Algebraic Approach to Revising Formal Ontologies: Application in Mereotopology

AI
In ontology engineering, reusing (or extending) ontologies poses a significant challenge, requiring revising their ontological commitments and ensuring accurate representation and coherent reasoning.
Gonzalo A. Aranda-Corral, Joaquín Borrego-Díaz, Antonia M. Chávez-González, Nataliya M. Gulayeva   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Ontology design patterns to disambiguate relations between genes and gene products in GENIA

Journal of Biomedical Semantics, 2011
Motivation Annotated reference corpora play an important role in biomedical information extraction. A semantic annotation of the natural language texts in these reference corpora using formal ontologies is challenging due to the inherent ambiguity of ...
Hoehndorf Robert, Ngonga Ngomo Axel-Cyrille, Pyysalo Sampo, Ohta Tomoko, Oellrich Anika, Rebholz-Schuhmann Dietrich   +5 more
doaj   +1 more source

Application of an Improved Formal Model of the Hybrid Development of Ontologies in Complex Information Systems

Applied Sciences, 2020
Ontologies in artificial intelligence systems are an effective way to represent and integrate knowledge and data. The property of such structures is that any subject area is accurately described in formal language.
Yousef Ibrahim Daradkeh, Iryna Tvoroshenko   +1 more
doaj   +1 more source

Ontology-driven development of dialogue systems

South African Computer Journal, 2023
A new technique and its software implementation are presented to create a deeply semantically structured ontology using plain natural language text as input, without regular structure or any previous tagging and markup.
Anna Litvin, Oleksandr Palagin, Vladislav Kaverinsky, Kyrylo Malakhov   +3 more
doaj   +1 more source

Using cross-lingual information to cope with underspecification in formal ontologies [PDF]

, 2003
Description logics and other formal devices are frequently used as means for preventing or detecting mistakes in ontologies. Some of these devices are also capable of inferring the existence of inter-concept relationships that have not been explicitly ...
Ceusters, Werner, Desimpel, Ignace, Schulz, Stefan, Smith, Barry   +3 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source