Results 141 to 150 of about 7,928 (214)

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

A multi-readout photonic sensor for rapid diagnosis of Von Willebrand disease. [PDF]

NPJ Biosens
Butt JN, Scott RL, Bryan MR, Steiner DJ, Bachmann R, Santonastaso B, Gatchell M, Refaai M, Miller BL.   +8 more
europepmc   +1 more source

Dynamic Reconstruction‐Engineered Heterointerfaces for Acidic Hydrogen Evolution at Ampere‐Level Current Density

Advanced Science, EarlyView.
A dynamic reconstruction strategy was utilized to construct PtCu/Cu3P heterostructures on the surface of self‐supporting Cu3P nanowires. The loose porosity in the restructured layer, together with a dynamic “dissolution‐redeposition” equilibrium during electrocatalysis, enables the electrode to maintain a low, stable overpotential for 240 h at ampere ...
Kaixi Wang, Yunshan Zheng, Chengzong Yuan, Kwun Nam Hui   +3 more
wiley   +1 more source

Comparative impact of white and black garlic on intestinal homeostasis: barrier protection, inflammation and microbiota modulation. [PDF]

Curr Res Food Sci
Girón-Hernández J, Mares-Bou S, Martelli A, Gentile P.   +3 more
europepmc   +1 more source

Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation

Advanced Science, EarlyView.
Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao, Zhengquan Wang, Hui Yang, Xiyuan Zhang, Hanyuan Liu, Xiaotong Lu, Xiaocheng Li, Yanyan Liu, Xi Zhao, Wenhao Zhou, Yufeng Zheng   +10 more
wiley   +1 more source

Fluidic torque-enabled object manipulation by microrobot collectives. [PDF]

Sci Adv
Ceron S, Gardi G, Petersen K, Sitti M.
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Accelerated Oxidative Degradation of Polystyrene: Correlating UV Aging with Reactive Molecular Dynamics. [PDF]

Molecules
Pasieczna-Patkowska S, Cichy M, Panczyk M, Nieszporek K, Panczyk T.   +4 more
europepmc   +1 more source

Nanopore‐Based Protein Deceleration and Sensing Using Graphene/Si3N4 Dual Membrane Cavity

Advanced Science, EarlyView.
A graphene/Si3N4 dual membrane cavity system achieves multi‐stage protein deceleration through spatial geometry. Multi‐level current traces provide high‐resolution spatial localization and early warning signals. ABSTRACT Sequencing of protein with nanopores has emerged as a powerful tool offering rapid readout, high accuracy, low cost, and portability.
Yubin Cao, Junzhou He, Wei Si
wiley   +1 more source

Study of Localized Corrosion Susceptibility of Ni-Based Superalloys Employing Electrochemical Noise Technique. [PDF]

Materials (Basel)
Almeraya-Calderon F, Huerta-Zavala MS, Maldonado-Bandala E, Nieves-Mendoza D, Jaquez-Muñoz JM, Baltazar-Zamora MA, Landa-Ruiz L, Estupinan-Lopez F, Olguin-Coca J, Flores-De Los Rios JP, Gaona-Tiburcio C.   +10 more
europepmc   +1 more source