Results 31 to 40 of about 494,717 (236)

Concurrent software fine‐coarse‐grained automatic modelling by Coloured Petri Nets for model checking

open access: yesIET Software, 2023
The state space explosion restricts the error detection of concurrent software. The abstraction can provide a solution to avoid state space explosion, but it is easy to ignore important details, resulting in inaccurate detection results.
Wenjie Zhong, Jian‐tao Zhou, Tao Sun
doaj   +1 more source

Towards Topology-Free Programming for Cyber-Physical Systems with Process-Oriented Paradigm

open access: yesSensors, 2023
The paper proposes a topology-free specification of distributed control systems by means of a process-oriented programming paradigm. The proposed approach was characterized, on the one hand, by a topologically independent specification of the control ...
Vladimir E. Zyubin   +3 more
doaj   +1 more source

From English to Formal Specifications [PDF]

open access: yesThe Computer Journal, 1994
Formal methods provide an approach in which design steps can be shown to satisfy a specification. However, if a formal specification is wrong, then although the design steps may satisfy the formal specification, they are unlikely to satisfy the requirements of the system.
Vadera, S, Meziane, F
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Formal Test Automation: The Conference Protocol with PHACT [PDF]

open access: yes, 2000
We discuss a case study of automatic test generation and test execution based on formal methods. The case is the Conference Protocol, a simple, chatbox-like protocol, for which (formal) specifications and multiple implementations are publicly available ...
Feenstra, Jan   +2 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Formal Specification and Verification of Self-Adaptive Concurrent Systems

open access: yesIEEE Access, 2018
The assurance of required quality properties is one of the major challenges in self-adaptive systems (SASs). SASs have the capability to adapt their dynamic behavior autonomously at runtime due to uncertain changes in the environment.
Muhammad Ilyas Fakhir   +1 more
doaj   +1 more source

Formal refinement of extended state machines [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2016
In a traditional formal development process, e.g. using the B method, the informal user requirements are (manually) translated into a global abstract formal specification. This translation is especially difficult to achieve.
Thomas Fayolle   +3 more
doaj   +1 more source

A Survey of Languages for Specifying Dynamics: A Knowledge Engineering Perspective [PDF]

open access: yes, 2000
A number of formal specification languages for knowledge-based systems has been developed. Characteristics for knowledge-based systems are a complex knowledge base and an inference engine which uses this knowledge to solve a given problem.
Engelfriet, Joeri   +6 more
core   +7 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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