Results 71 to 80 of about 2,084,052 (380)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

Concurrency specification using Event-based Specification Chart [PDF]

open access: yesComputer Science Journal of Moldova, 2012
Architecting framework proposed in [1] can be used efficiently for developing concurrency-intensive systems only if there exist languages and tools corresponding to the described concepts.
Dumitru Ciorba, Victor Besliu
doaj  

Formal Specification and Verification of Self-Adaptive Concurrent Systems

open access: yesIEEE Access, 2018
The assurance of required quality properties is one of the major challenges in self-adaptive systems (SASs). SASs have the capability to adapt their dynamic behavior autonomously at runtime due to uncertain changes in the environment.
Muhammad Ilyas Fakhir   +1 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Formal Synthesis of Stochastic Systems via Control Barrier Certificates [PDF]

open access: yesIEEE Transactions on Automatic Control, 2019
This article focuses on synthesizing control policies for discrete-time stochastic control systems together with a lower bound on the probability that the systems satisfy the complex temporal properties. The desired properties of the system are expressed
Pushpak Jagtap   +2 more
semanticscholar   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

open access: yesMolecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa   +14 more
wiley   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

open access: yesFEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez   +5 more
wiley   +1 more source

Method specification for automated evaluation of documents formal quality

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2009
Automated documents processing allows production of large amount of documents. Formal quality of the documents is very important as it contributes to better understanding and information transmission.
Petra Talandová, Jiří Rybička
doaj   +1 more source

AR2B: FORMALIZATION OF ARABIC TEXTS WITH EVENT-B

open access: yesJordanian Journal of Computers and Information Technology, 2020
Transforming natural software requirements into a more formal specification is difficult and may be an excellent application for natural language processing. This problem is not recent.
Kheira-Zineb Bousmaha Ossoukine   +1 more
doaj   +1 more source

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