Results 71 to 80 of about 820,561 (265)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Comicalités, 2011 Si le livre de poche a joué un rôle central dans la diffusion du patrimoine littéraire, la bande dessinée ne dispose pas de cet outil permettant la constitution d’un corpus de classiques aisément accessibles au plus grand nombre.
Sylvain Lesage
doaj
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Guidance on Data Exchange version 2.0
EFSA Journal, 2014 Data collection is an important task of EFSA and a fundamental component of many of its risk assessment activities. Transparency and openness regarding the way in which data are collected and analysed are underlying principles of EFSA's operations.
European Food Safety Authority
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
How Near Will You Hear? A Response to Benadon, "Near-unisons in Afro-Cuban Ensemble Drumming"
Empirical Musicology Review, 2017 Fernando Benadon (2016) shines a strong objective light onto slight but noticeable timing perturbations in Afro-Cuban drumming practice, coining the term near-unisons to describe non-simultaneous attacks that are perceived as such, but that are also ...
Peter Martens
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Development of BCMA-Targeted Bispecific Natural Killer Cell Engagers for Multiple Myeloma Treatment
AntibodiesBackground: B-cell maturation antigen (BCMA)-targeted T cell-redirecting immunotherapies, including Chimeric Antigen Receptor (CAR) T-cell therapy and T-cell engagers have demonstrated remarkable success in treating relapsed/refractory (RR) multiple ...
Minchuan Zhang +5 more
doaj +1 more source
Symposium - International Astronomical Union, 1987 Theories of galaxy formation via hierarchical clustering of cold dark matter and by fragmentation of gaseous pancakes or shells are reviewed and compared. Dissipative processes are crucial to all theories of galaxy formation, and are discussed in terms of a simple model involving multiple cloud interactions.
openaire +1 more source