Results 111 to 120 of about 8,358,442 (291)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Differential effects of dual and synergist-based insecticide-treated bed nets on pyrethroid resistance and L995F/S knockdown resistance mutation dynamics in Anopheles gambiae s.l. populations in south-western Burkina Faso

Parasites & Vectors
Background The introduction of next-generation insecticide-treated nets (ITNs) in Burkina Faso aims to mitigate pyrethroid resistance in malaria vectors.
Madou Tapsoba, Wamdaogo Moussa Guelbeogo, Antoine Sanou, Soumanaba Zongo, Christelle Gogue, Siaka Debe, Kyra Arnett, Kelly Davis, Jenny Shannon, Peder Digre, Julia Mwesigwa, Kenzie Tynuv, Christen Fornadel, Sagnon N’Falé, Molly Robertson, Joseph D. Challenger, Gauthier Tougri, Adama Gansané, Hilary Ranson, Gnankiné Olivier, Joseph Wagman   +20 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Epidémiologie et recherche sur la tuberculose au Mali: Etat des lieux

Revue Malienne d’Infectiologie et de Microbiologie, 2015
La tuberculose reste un problème de santé publique au Mali malgré les bons scores enregistrés ces dernières années aussi bien dans la lutte que dans la recherche contre la maladie.
Seydou Diabaté, Bocar Baya, Moumine Sanogo, Bassirou Diarra, Yacouba Toloba, Gaoussou Berthé, et.al.   +6 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Secteur de formation 15 : mines et travaux de chantier

, 2008
Titre de l'écran-titre (visionné le 21 août 2008)"Secteur de formation 15 : mines et travaux de ...
Pouliot, Jean-François, Bouchard, Serge,, Québec (Province). Formation professionnelle et technique et formation continue. Direction générale de la formation professionnelle et technique, St-Pierre, Lyne, Cauchon, Michel   +4 more
core   +1 more source

Three-year trends in malaria transmission parameters under deployment of Interceptor®G1, Interceptor®G2 and PermaNet®3.0 insecticide-treated bed nets in South-Western Burkina Faso

Malaria Journal
Background In South-Western Burkina Faso, where malaria remains highly endemic, the widespread resistance of Anopheles mosquitoes to pyrethroid is reducing the effectiveness of insecticide-treated nets (ITNs).
Madou Tapsoba, Wamdaogo Moussa Guelbeogo, Antoine Sanou, Soumanaba Zongo, Christelle Gogue, Siaka Debe, Kyra Arnett, Kelly Davis, Jenny Shannon, Peder Digre, Julia Mwesigwa, Kenzie Tynuv, Christen Fornadel, Sagnon N’Falé, Molly Robertson, Joseph D. Challenger, Gauthier Tougri, Adama Gansané, Hilary Ranson, Gnankiné Olivier, Joseph Wagman   +20 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Secteur de formation 8 : environnement et aménagement du territoire

, 2008
Titre de l'écran-titre (visionné le 21 août 2008)"Secteur de formation 8 : environnement et aménagement du ...
Québec (Province). Formation professionnelle et technique et formation continue. Direction générale de la formation professionnelle et technique, Gingras, Marielle, Houle, Christian   +2 more
core   +1 more source