Results 121 to 130 of about 9,333,414 (344)

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

An Improved Model to Simulate Mud (Drilling Fluid) Dispersion through Porous Media [PDF]

open access: yesIranian Journal of Chemistry & Chemical Engineering, 2010
An improved model of mud dispersion has been introduced in this work. The advantages of this model consist of a new analytical correlation for dispersivity by using resistivity log data and using a new aspect of capacitance dispersion model. Mathematical
Mohammad Zahedzadeh   +3 more
doaj  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Occurrence and Characterization of Paraffin Wax Formed in Developing Wells and Pipelines

open access: yesEnergies, 2019
Deposition and precipitation of paraffin wax in pipelines are major problems in the production, transfer, storage, and processing of crude oil. To prevent complete clogging, it is necessary to minimize and remove deposited wax in pipelines and tubing ...
Marwa M. El-Dalatony   +6 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Formation Damage due to Drilling and Fracturing Fluids and Its Solution for Tight Naturally Fractured Sandstone Reservoirs

open access: yes, 2017
Drilling and fracturing fluids can interact with reservoir rock and cause formation damage that impedes hydrocarbon production. Tight sandstone reservoir with well-developed natural fractures has a complex pore structure where pores and pore throats have
Tianbo Liang   +6 more
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

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