Results 71 to 80 of about 36,099 (169)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Why is the Star Formation Rate Proportional to Dense Gas Mass?

The Astrophysical Journal
One of the most profound empirical laws of star formation is the Gao–Solomon relation, a linear correlation between the star formation rate (SFR) and the dense molecular gas mass.
Sihan Jiao, Fengwei Xu, Hauyu Baobab Liu, Yuxin Lin, Jingwen Wu, Zhi-Yu Zhang, Zhiqiang Yan, Di Li, Chao-Wei Tsai, Yongkun Zhang, Linjing Feng, Ke Wang, Zheng Zheng, Fanyi Meng, Hao Ruan, Fangyuan Deng, Keyun Su   +16 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

CEERS: 7.7 μm PAH Star Formation Rate Calibration with JWST MIRI

The Astrophysical Journal
We test the relationship between UV-derived star formation rates (SFRs) and the 7.7 μ m polycyclic aromatic hydrocarbon luminosities from the integrated emission of galaxies at z ∼ 0–2. We utilize multiband photometry covering 0.2–160 μ m from the Hubble
Kaila Ronayne, Casey Papovich, Guang Yang, Lu Shen, Mark Dickinson, Robert Kennicutt, Anahita Alavi, Pablo Arrabal Haro, Micaela B. Bagley, Denis Burgarella, Aurélien Le Bail, Eric F. Bell, Nikko J. Cleri, Justin Cole, Luca Costantin, Alexander de la Vega, Emanuele Daddi, David Elbaz, Steven L. Finkelstein, Norman A. Grogin, Benne W. Holwerda, Jeyhan S. Kartaltepe, Allison Kirkpatrick, Anton M. Koekemoer, Ray A. Lucas, Benjamin Magnelli, Bahram Mobasher, Pablo G. Pérez-González, Laura Prichard, Marc Rafelski, Giulia Rodighiero, Ben Sunnquist, Harry I. Teplitz, Xin Wang, Rogier A. Windhorst, L. Y. Aaron Yung   +35 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Cosmological Evolution of Fast Radio Bursts and the Star Formation Rate

The Astrophysical Journal Letters
We investigate the cosmological evolution of the luminosity and redshift of fast radio bursts (FRBs). As is the case for all extragalactic sources, we are dealing with data that are truncated by observational selection effects, the most important being ...
Sujay Champati, Vahé Petrosian
doaj   +1 more source