Results 101 to 110 of about 1,068,274 (302)

Numerical modelling of T-pipe joints forming

open access: yesMATEC Web of Conferences, 2018
This paper presents results of numerical calculations of T-pipe joints (tee) forming process for a wide scope of industrial applications. FEM analyses were conducted for the chosen process technological parameters and tools designs.
Bartnicki Jarosław
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Selection schemes of formation hollow parts with the taperid surface

open access: yesВестник СибАДИ, 2017
It describes different technologies obtained by cold forming of hollow parts with conical surfaces of solid and tubular billets, analyzed the advantages and disadvantages of certain methods of deformation.
A. V. Evstifeev   +2 more
doaj   +1 more source

Dynamics and correlation length scales of a glass-forming liquid in quiescent and sheared conditions

open access: yes, 2012
We numerically study dynamics and correlation length scales of a colloidal liquid in both quiescent and sheared conditions to further understand the origin of slow dynamics and dynamic heterogeneity in glass-forming systems.
An, Li-Jia, Sun, Zhao-Yan, Xu, Wen-Sheng
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

THE EVOLUTION TRAJECTORY STABILITY FOR MECHANICAL SYSTEM INTERACTING WITH TRIBOMEDIA

open access: yesВестник Донского государственного технического университета, 2018
Conditions of motion stability loss is considering relative to mechanical system, interacting with media, forming in tribocoupling. Conditions of forming and role of dissipative, gyroscopic, potential and circular forces, which formed naturally in ...
V.L. ZAKOVOROTNY   +2 more
doaj  

A Study on the Influence of the Forming Strategy on the Main Strains, Thickness Reduction, and Forces in a Single Point Incremental Forming Process

open access: yesAdvances in Materials Science and Engineering, 2013
This paper comprises an experimental study for a complex geometry part obtained by incremental forming. Due to the process complexity (the presence of forces on three directions—a vertical one and two in the blank's plane), a three axes CNC milling ...
Adrian Blaga, Valentin Oleksik
doaj   +1 more source

State position on the existing contradictions of operational staff as governing body of modern regional law enforcement forces

open access: yesТеорія і практика правознавства, 2016
We consider the contradictions existing state position on the use of the operations staff as the governing body of modern regional law enforcement forces and trends in substance to overcome them are the following: a) the essence contradictions that arise
Микола Михайлович Орлов
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

THE EVOLUTION TRAJECTORY STABILITY FOR MECHANICAL SYSTEM INTERACTING WITH TRIBOMEDIA

open access: yesAdvanced Engineering Research, 2007
Conditions of motion stability loss is considering relative to mechanical system, interacting with media, forming in tribocoupling. Conditions of forming and role of dissipative, gyroscopic, potential and circular forces, which formed naturally in ...
V.L. ZAKOVOROTNY   +2 more
doaj  

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