Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Energy-Consistent Neural Networks with Fenchel-Young Loss for Physics-Guided Energy Prediction in Sheet Metal Forming Under Small-Data Conditions. [PDF]
Materials (Basel)Jhang SS, Kwon JY, Lee WH, Park HG.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Real-Time Transient Voltage and Frequency Sensing Strategy for Resilience Enhancement of PV-Storage Systems in Weak Grids. [PDF]
Sensors (Basel)Ji Y +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Bacterial and host factors affecting acquisition of <i>Streptococcus pneumoniae</i> in a murine model. [PDF]
Infect ImmunFecko DP, Wu C, Weiser JN.
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Design of a Wireless Ultraviolet Germicidal Irradiation System and Validation of Germicidal Potential Against Biofilm-Forming Bacteria and Fungi. [PDF]
Antibiotics (Basel)Sadanandan B +5 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Process Design of Vinyl-Coated Metal Sheet Stamping for Prevention of Delamination and Wrinkling by DNN-Based Multi-Objective Optimization. [PDF]
Materials (Basel)Kim MG, Ryu JC, Lee CJ, Jang JS, Ko DC.
europepmc +1 more source