Results 41 to 50 of about 179,053 (269)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Amino acid formulas in patients with food allergy
Педиатрическая фармакология, 2021 The article presents modern approaches to the use of balanced formulas for nutrition and diet correction in children with various forms of food allergies.
Alexander A. Baranov +41 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The Journal of Geometric Analysis, 2023 Let $φ$ be a quasi-psh function on a complex manifold $X$ and let $S\subset X$ be a complex submanifold. Then the multiplier ideal sheaves $\mathcal{I}(φ|_S)\subset\mathcal{I}(φ)|_{S}$ and the complex singularity exponents $c_{x}\left(φ|_{S}\right)\leqslant c_{x}(φ)$ by Ohsawa-Takegoshi $L^{2}$ extension theorem.
Xiankui Meng, Xiangyu Zhou
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A subconjunctival foreign body confused with uveal prolapse
Indian Journal of Ophthalmology, 2014 There are cases in which the presence of a foreign body (FB) is difficult to diagnose based on history taking or clinical examination. We report a case of subconjunctival FB confused with uveal prolapse.
Young Min Park +3 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Indian Journal of Ophthalmology, 2014 A 70-year-old female patient presented with proptosis of right eye for the past 15 days and defective vision in both eyes since birth. She was found to have eccentric painful proptosis of right eye along with features of oculocutaneous albinism ...
J Saravanan +2 more
doaj +1 more source
Proceedings of the Glasgow Mathematical Association, 1954 In this paper I construct a reduction formula for the integralthe formula connects any three consecutive members of a set I0, I1, I2, …, Im. We regard m as given, and, in order to avoid wasting time over trivialities, we postulate that the constants a, α, β, γ δ (which are not restricted to be real) have real parts large enough to ensure (i) that the ...
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source