Results 41 to 50 of about 20,127 (298)

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Rocca Savelli (Aventine Hill). Contribution to the knowledge on defence systems for family goods in Rome during the late Middle Ages

Groma, 2023
This paper concerns the results of the archaeological investigations at the Savelli fortress on the Aventine Hill in Rome. This fortification surrounds a well-known park of the city: the Giardino degli Aranci.
Andrea Fiorini
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Fortifications : G. Coppola, G. Muollo, Fortifications en Italie normande

, 1995
Leroy Laurence. Fortifications : G. Coppola, G. Muollo, Fortifications en Italie normande. In: Annales de Normandie, 45ᵉ année, n°2, 1995. La pierre de Caen. pp.
Leroy, Laurence
core   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

GERONA. Estrategia militar. 1:6.300 (1809) [PDF]

Comprende la ciudad de Gerona y parte de sus alrededores, destacando las fortificaciones en ella existentesEscala gráfica también dada en toesasRelieve representado por curvas de nivel, puntos acotados, normales y sombreadoIndica las principales ...
Barrière, Isabelle, Francia. Depot des fortifications   +1 more
core   +2 more sources

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Geometry and construction: mental models and types realized in defence territories

Disegnare con, 2012
Two strong concepts like “geometry” and “architecture” can be enhanced if they are correlated to each other, especially if the link between them is the word “construction”.
Anna Marotta
doaj   +1 more source

Sn‐Driven Grain Boundary Elimination for Single‐Crystalline Ni‐Rich Cathodes with Superior High‐Voltage Stability in Lithium‐Ion Batteries

Advanced Science, EarlyView.
A low‐temperature synthesis method of single‐crystalline NCA was successfully achieved by Sn doping, employing the same synthetic conditions as its polycrystalline counterparts. This synthesis was conducted at a temperature that was 150 °C lower than that required for synthesizing single‐crystalline NCA without Sn doping.
Guomeng Xie, Delai Qian, Ruiwu Li, Terence Xiaoteng Liu, Shun Lu   +4 more
wiley   +1 more source

About the meaning of fortifications in late antique cities: the case of Athens in context

, 2016
Like many other centres in Greece and elsewhere in the Roman Empire, Athens strengthened its fortifications in the 3rd century AD in the face of the barbarian threat. Later the city received a reduced wall circuit that included only a small part of the
BALDINI, ISABELLA, Elisa Bazzechi
core   +1 more source