Results 81 to 90 of about 211 (190)

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu   +4 more
wiley   +1 more source

Voice quality types and uses in North American English. [PDF]

open access: yesAnglophonia, 2019
Wright R, Mansfield C, Panfili L.
europepmc   +1 more source

Impact of after‐school care on maternal income: Evidence from Canadian administrative data

open access: yesCanadian Journal of Economics/Revue canadienne d'économique, EarlyView.
Abstract This paper estimates the average causal effect of access to subsidized before‐ and after‐school care on the labour market outcomes of mothers. Specifically, we analyze a major policy reform implemented in Quebec (Canada) in 1998, which required all public primary schools to provide before‐ and after‐school care at a low fixed fee, thereby ...
Ailin He, Laetitia Renée, Nagham Sayour
wiley   +1 more source

Technology Matters: Integrating digital treatments for children and young people with anxiety disorders into routine care

open access: yesChild and Adolescent Mental Health, EarlyView.
Anxiety disorders in children and young people are common and impairing. Cognitive behavioural therapy (CBT) is the recommended first‐line treatment and the past two decades have seen numerous digital CBT interventions emerge. Digital CBT has the potential to improve access, reduce waiting times and scale services.
Per Andrén   +2 more
wiley   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

open access: yesCancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal   +16 more
wiley   +1 more source

Allophony in English Language Learners: The Case of Tap in English and Spanish. [PDF]

open access: yesLang Speech Hear Serv Sch, 2019
Burrows L, Jarmulowicz L, Oller DK.
europepmc   +1 more source

Licence Loss: Revocations of Residential Care Licences in Four Nordic Countries

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT With placement in residential care, society assumes overall responsibility for a child's daily care, well‐being and development. How public authorities respond to poor care quality is of crucial importance. To guarantee quality care and minimise risks, welfare states increasingly develop different mechanisms and systems to supervise out‐of ...
David Pålsson   +5 more
wiley   +1 more source

Negotiating Responsibility: Professionals' Perspectives on Separated Parents' Protective Duties in the Swedish Context

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT This study explores how social workers perceive and enact informal protective arrangements in the context of Swedish child protection. Drawing on group interviews with practitioners, the findings reveal that social workers underline parents' legal obligation and duty to protect their children, which means that the safe parent is expected to ...
Emma Rindeskog, Lupita Svensson
wiley   +1 more source

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