Results 31 to 40 of about 38,604 (218)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Forward–Backward–Forward Algorithm for Quasi-Variational Inequalities in the Moving Set Case

Mathematics
This paper addresses the challenge of solving quasi-variational inequalities (QVIs) by developing and analyzing a forward–backward–forward algorithm from a continuous and iterative perspective.
Nevena Mijajlović, Ajlan Zajmović, Milojica Jaćimović   +2 more
doaj   +1 more source

Research on Dynamic Incremental Backward Cloud Transformation Algorithm [PDF]

Jisuanji kexue
As a tool for studying uncertain information,cloud model is of great significance in uncertain artificial intelligence and data mining.The backward cloud transformation algorithm is one of the important algorithms of cloud model,which can realize the ...
XU Changlin, KONG Lingzhuo
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

On the Concatenated Transmission Scheme With the Low-Complexity Symbol-Level Watermark Decoder for Recovering the Synchronization

IEEE Access, 2019
The Davey–MacKay (DM) concatenated code employing the symbol-level watermark decoding algorithm is able to correct a large number of binary insertions, deletions, and substitutions, while it has the high computational complexity for recovering the
Yuan Liu
doaj   +1 more source

Shape Optimization of Labyrinth Seals to Improve Sealing Performance

Aerospace, 2021
To reduce gas leakage, shape optimization of a straight labyrinth seal was carried out. The six design parameters included seal clearance, fin width, fin height, fin pitch, fin backward, and forward expansion angle. The CFD (Computational Fluid Dynamics)
Yizhen Zhao, Chunhua Wang
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

Modular Algebraic Precoding Relay System Model Based on Lattice Reduction

IEEE Access, 2018
According to the existing multi-antenna relay forwarding protocol, the relay matrix can be split into two parts-relay nodes forward and backward filters direct concatenation, then in actual channel matrix design, relay's forward and backward channel ...
Chaoyi Zhang, Yili Zheng, Yan Yao
doaj   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source