Results 61 to 70 of about 118,136 (346)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Isolated DC-DC UPS based in a forward-forward converter analysis and design [PDF]

open access: yes, 2008
This paper presents the analysis, design and simulation from a simple DC-UPS converter with integrated back-up and automatic transition. This converter makes automatic transition between the main AC and the battery when a failure occurs, and it delivers ...
Esparza González, Mario S.   +3 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Control Strategies for the DAB Based PV Interface System. [PDF]

open access: yesPLoS ONE, 2016
This paper presents an interface system based on the Dual Active Bridge (DAB) converter for Photovoltaic (PV) arrays. Two control strategies are proposed for the DAB converter to harvest the maximum power from the PV array. The first strategy is based on
Hadi M El-Helw   +2 more
doaj   +1 more source

Single-Stage Grid-Connected Forward Microinverter with Boundary Mode Control [PDF]

open access: yes, 2011
This paper presents a microinverter to be integrated into a solar module. The proposed solution combines a forward converter and a constant off-time boundary mode control, providing MPPT capability and unity power factor in a single-stage converter.
Alou Cervera, Pedro   +5 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

A High-Power-Density Active-Clamp Converter with Integrated Planar Transformer

open access: yesEnergies, 2022
This paper proposes an active-clamp forward-flyback (ACFF) converter with an integrated planar transformer for wide-input voltage and high-output current applications, such as low-voltage direct-current (LDC) converters in electric vehicles.
Dae-Woo Lee   +3 more
doaj   +1 more source

ACL command with forward converter [PDF]

open access: yes, 2009
Objectif: Les ACL sont des lampes 28V/250W utilisées dans le domaine de l’éclairage scénique. Jusqu’à présent 8 lampes sont branchées en série sur le réseau ce qui interdit toute commande individuelle. L’appareil conçu dans ce projet contient un « Power Factor Corrector PFC » pour pouvoir créer un bus de tension à 400V et un convertisseur de type ...
Morard, Julien, Biner, Hans-Peter
openaire  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

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