Results 231 to 240 of about 357,951 (287)

Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle

open access: yesAdvanced Science, EarlyView.
This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia   +39 more
wiley   +1 more source

Uncertainty-aware Fourier ptychography. [PDF]

open access: yesLight Sci Appl
Chen N   +5 more
europepmc   +1 more source

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

open access: yesAdvanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan   +19 more
wiley   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

open access: yesAdvanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria   +5 more
wiley   +1 more source

Theta-frequency subthalamic stimulation enhances conflict resolution in Parkinson's disease patients with freezing of gait through frontal cortex modulation. [PDF]

open access: yesNPJ Parkinsons Dis
Xie H   +14 more
europepmc   +1 more source

Self‐Powered UV Dual‐Band Photodetector Based on Cs3BiCl6/GaN Heterojunction for Logical Operation and Encrypted Photo‐Communication

open access: yesAdvanced Science, EarlyView.
Utilizing the special dual‐band absorption characteristics of Cs3BiCl6 and its strong surface‐charge recombination behavior, a self‐powered UV dual‐band photodetector based on Cs3BiCl6/GaN heterojunction is developed. As a result, the photodetector exhibits excellent specific detectivity of 1.23 × 1012 Jones and ultrafast response speed of τr/τf = 28 ...
Jingli Ma   +11 more
wiley   +1 more source

Clarifying methodological discrepancies in HIV retention analysis-authors' reply. [PDF]

open access: yesLancet Reg Health Southeast Asia
Chidrawar S   +4 more
europepmc   +1 more source

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

open access: yesAdvanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan   +16 more
wiley   +1 more source

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