Results 121 to 130 of about 29,606,688 (333)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

Trajectory Control of Flexible Manipulators Using Forward and Inverse Models with Neural Networks

open access: yesVibration
This study explores trajectory control in flexible manipulators using neural-network-based forward and inverse modeling. Unlike traditional approaches that enhance precision by increasing structural rigidity—often at the cost of added weight and energy ...
Minoru Sasaki   +3 more
doaj   +1 more source

Simultaneous Learning and Filtering without Delusions: A Bayes-Optimal Derivation of Combining Predictive Inference and AdaptiveFiltering

open access: yesFrontiers in Computational Neuroscience, 2015
Predictive coding appears to be one of the fundamental working principles of brain processing. Amongst other aspects, brains often predict the sensory consequences of their own actions. Predictive coding resembles Kalman filtering, where incoming sensory
Jan eKneissler   +3 more
doaj   +1 more source

THE COST OF FORWARD CONTRACTING [PDF]

open access: yes
The cost of forward contracting corn is estimated with weekly pre-harvest forward bases for seven regions of Illinois from 1975 to 2002. Given the panel structure of the forward basis dataset, we extend Townsend and Brorsen's univariate unit root model ...
Good, Darrel L.   +3 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Physics-Guided Machine Learning-Based Forward-Modeling of Radar Observables: A Case Study on Sentinel-1 Observations of Corn-Fields

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Artificial neural networks have the potential to model the interaction of radar signals with vegetation but often do not follow the physical rules. This article aims to develop a new physics-guided machine learning approach that combines neural networks ...
Tina Nikaein, Paco Lopez-Dekker
doaj   +1 more source

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