Results 201 to 210 of about 2,187,371 (360)

Bidentate NHC‐Containing Ligands for Copper Catalysed Synthesis of Functionalised Diaryl Ethers

open access: yesAdvanced Synthesis &Catalysis, Volume 367, Issue 6, March 18, 2025.
Abstract Diaryl and heteroaryl ethers are important and common motifs in drug discovery and agrochemicals. Here we present a catalytic system for the copper catalysed arylation of phenols with aryl halides. Bidentate N‐heterocyclic carbene ligands provide a well‐defined catalytic system that enable low loading of copper in effective coupling reactions (
Ethan M. Richards   +8 more
wiley   +1 more source

Metal‐Free, Selective Ortho‐Deuteration of N‐Heterocyclic Oxides

open access: yesAdvanced Synthesis &Catalysis, Volume 367, Issue 6, March 18, 2025.
Abstract Replacing hydrogen with deuterium raises the activation energy for C−D bond cleavage. This approach has gained attention in drug design, especially to protect the ortho‐position of pyridines, which are susceptible to enzymatic oxidation.
Arianna Montoli   +5 more
wiley   +1 more source

Exchange rates, credit default swaps and market volatility of emerging markets: Panel CS-ARDL approach

open access: yesBorsa Istanbul Review
Using the panel-data approach with a sample of emerging countries, this study examines the relationship between exchange-rate movements from 2011 to 2022, on the one hand, and sovereign debt credit default swap (CDS) premiums and market volatility, on ...
Alan T. Wang, Chin-Chia Liang
doaj  

FMint: Bridging Human Designed and Data Pretrained Models for Differential Equation Foundation Model for Dynamical Simulation

open access: yesAdvanced Theory and Simulations, EarlyView.
FMint is introduced as a multi‐modal foundation model that integrates human‐designed solvers and data‐driven methods for fast, accurate simulation of dynamical systems. FMint leverages in‐context learning within a transformer‐based framework to refine coarse numerical solutions.
Zezheng Song, Jiaxin Yuan, Haizhao Yang
wiley   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

open access: yesAdvanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu   +8 more
wiley   +1 more source

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