Results 1 to 10 of about 174,090 (197)

Identification of Oxidative Stress-Related Biomarkers for Pain-Depression Comorbidity Based on Bioinformatics. [PDF]

Int J Mol Sci
Oxidative stress has been identified as a major factor in the development and progression of pain and psychiatric disorders, but the underlying biomarkers and molecular signaling pathways remain unclear.
Zhang T, Geng M, Li X, Gu Y, Zhao W, Ning Q, Zhao Z, Wang L, Zhang H, Zhang F.   +9 more
europepmc   +2 more sources

Protection of c-Fos from autophagic degradation by PRMT1-mediated methylation fosters gastric tumorigenesis

International Journal on Biological Sciences, 2023
Both AP-1 and PRMT1 are vital molecules in variety of cellular progresssion, but the interaction between these proteins in the context of cellular functions is less clear. Gastric cancer (GC) is one of the pernicious diseases worldwide.
Eunji Kim, L. Rahmawati, N. Aziz, H. Kim, Ji hye Kim, Kyung-Hee Kim, B. Yoo, N. Parameswaran, Jong-Sun Kang, Hoon Hur, Balachandran Manavalan, Jongsung Lee, Jae Youl Cho   +12 more
semanticscholar   +1 more source

Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis

International Journal on Biological Sciences, 2022
Cathepsins play a role in regulation of cell function through their presence in the cell nucleus. However, the role of Cathepsin K (Ctsk) as an epigenetic regulator in osteoclasts remains unknown.
G. Zhu, Wei Chen, Chen-Yi Tang, A. McVicar, Diep N. Edwards, Jinwen Wang, Matthew McConnell, Shuying Yang, Yang Li, Z. Chang, Yi-Ping Li   +10 more
semanticscholar   +1 more source

Analysis of Under-Diagnosed Malignancy during Fine Needle Aspiration Cytology of Lymphadenopathies

International Journal of Molecular Sciences, 2023
Fine needle aspiration cytology (FNAC) is a useful tool in the evaluation of lymphadenopathy. It is a safe and minimally invasive procedure that provides preoperative details for subsequent treatment. It can also diagnose the majority of malignant tumors.
Jeeyong Lee, Hwa-jeong Ha, Da Yeon Kim, J. Koh, Eun Ju Kim   +4 more
semanticscholar   +1 more source

Assessment of the Response of Human Umbilical Vein Endothelial Cells to Photodynamic Therapy: Highlighting the Role of Il-17 Signaling Pathway.

Journal of lasers in medical sciences, 2023
Introduction: Photodynamic therapy (PDT) is a method based on the application of a photosensitive agent and the administration of light irradiation on the treated samples.
Mona Zamanian Azodi, B. Arjmand, M. Hamzeloo-Moghadam, M. Rezaei Tavirani, Zahra Razzaghi, Alireza Ahmadzadeh, Reza M Robati, Majid Rezaei Tavirani   +7 more
semanticscholar   +1 more source

Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Human cytomegalovirus (HCMV) is a widespread pathogen that remains with an individual for life in a quiescent/latent state, posing little threat to an otherwise healthy person.
B. Krishna, Monica S Humby, W. Miller, C. O’Connor   +3 more
semanticscholar   +1 more source

Umbelliferone Prevents Lipopolysaccharide-Induced Bone Loss and Suppresses RANKL-Induced Osteoclastogenesis by Attenuating Akt-c-Fos-NFATc1 Signaling

International Journal on Biological Sciences, 2019
Excessive bone resorption plays a central role in the development of inflammatory bone diseases, including osteoporosis and rheumatoid arthritis. Thus, identification of agents that can effectively suppress excessive osteoclast formation and function is ...
S. Kwak, J. Baek, C. Lee, K. Yoon, Myeung-Su Lee, Ju-Young Kim   +5 more
semanticscholar   +1 more source

Inhibitory Effect of Purpurogallin on Osteoclast Differentiation In Vitro through the Downregulation of c-Fos and NFATc1

International Journal of Molecular Sciences, 2018
Purpurogallin, a benzotropolone-containing natural compound, has been reported to exhibit numerous biological and pharmacological functions, such as antioxidant, anticancer, and anti-inflammatory effects.
Kiryeong Kim, Tae Hoon Kim, H. Ihn, Jung Eun Kim, Je-Yong Choi, Hong-In Shin, E. Park   +6 more
semanticscholar   +1 more source

Nanoluciferase Reporter Gene System Directed by Tandemly Repeated Pseudo-Palindromic NFAT-Response Elements Facilitates Analysis of Biological Endpoint Effects of Cellular Ca2+ Mobilization

International Journal of Molecular Sciences, 2018
NFAT is a cytoplasm-localized hyper-phosphorylated transcription factor that is activated through dephosphorylation by calcineurin, a Ca2+/calmodulin-dependent phosphatase. A non-palindromic NFAT-response element (RE) found in the IL2 promoter region has
Wei Zhang, Terunao Takahara, Takuya Achiha, H. Shibata, M. Maki   +4 more
semanticscholar   +1 more source

Study and determination of fructan-type polysaccharide content in Erigeron annuus L

Current Issues in Pharmacy and Medical Sciences, 2022
Fructan-type polysaccharidescomes from natural sources and occur in a large variety of plants, where they play important biological roles as reserve carbohydrate.
S. Kovalev, A. Golovach, Vladimir Kovalev, E. Poleszak, E. Akhmedov, O. Bobrytska   +5 more
semanticscholar   +1 more source