Results 151 to 160 of about 32,095 (217)

The X‐Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two‐Component Flavin‐Dependent Tryptophan Halogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma, Emily W. Rady, Aravinda J. de Silva, John J. Bellizzi III   +3 more
wiley   +1 more source

HEXIM1/P-TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization. [PDF]

J Biol Chem
Htet M, Estay-Olmos C, Hu L, Wu Y, Powers BE, Campbell CD, Rameshwar A, Ahmed MR, Hohman TJ, Wang Y, Schneider JA, Bennett DA, Menon V, De Jager PL, Kaas GA, Colbran RJ, Greer CB.   +16 more
europepmc   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Overexpression of IGF2 Alters the Transcriptional Profile of Goose Skeletal Muscle Satellite Cells. [PDF]

Biomolecules
Wang C, Liu Y, Yang Y, Chen S, He D.
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Oligosaccharide prebiotics in functional foods and therapeutics: innovations and challenges. [PDF]

3 Biotech
Sandra KS, Vithalkar MP, Beere V, Bharath HB, Satyanarayana B, Rafiq M, Nayak Y.   +6 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Transcranial Direct Current Stimulation Targeting the Primary Motor Cortex Suppresses Activity in the Ventrolateral Periaqueductal Gray and Alleviates Chronic Pain in a Rat Model of Knee Osteoarthritis. [PDF]

J Pain Res
Xu Y, Fan C, Xue J, Gao C, Zhou Y, Li T.
europepmc   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source

Biosynthesis of fosfomycin-loaded CuO nanoparticles: evaluation of antibacterial, antibiofilm properties and molecular docking analysis against biofilm-associated proteins in MDR bacteria. [PDF]

Asian Biomed (Res Rev News)
Abbasi Z, Fasim F, Abbas S, Shafique R, Khan BA, Nisar A, Alshahrani SM, Uzair B.   +7 more
europepmc   +1 more source