Results 31 to 40 of about 26,336 (149)
Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain
Advanced Science, EarlyView.Ce‐UiO‐66‐Bupivacaine (CUB) demonstrates triple therapeutic innovation: 1) Sustained analgesia with ROS scavenging synergistically resolves neuropathic pain; 2) Microglia/astrocyte polarization switch reprograms the pro‐regenerative immune microenvironment; 3) CGRP‐TSP‐1 axis activation couples inflammation suppression to axon regeneration, defining a ...
Yue Wang +9 more
wiley +1 more source
Advanced Science, EarlyView.This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu +7 more
wiley +1 more source
Advanced Science, EarlyView.Patients with osteoporosis face a higher risk of bone injury, mainly due to weakened osteogenic differentiation and bone formation, along with increased osteoclast differentiation and bone resorption activity, leading to bone homeostasis imbalance.
Xinhui Wu +13 more
wiley +1 more source
Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury
Advanced Science, EarlyView.The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He +11 more
wiley +1 more source
High‐Density Flexible Neural Implants with Submicron Feedline Resolution
Advanced Electronic Materials, EarlyView.Optimization of microfabrication methods using optical contact lithography (OCL) and electron beam lithography (EBL) enables the fabrication of 64‐channel, high‐density, parylene‐C‐based intracortical implants with submicron feedlines as narrow as 400 and 50 nm, respectively.
Lina Koschinski +10 more
wiley +1 more source
Smart Transfemoral Prosthetic Socket with Motorized Cable‐Driven System
Advanced Intelligent Systems, EarlyView.This study presents an innovative transfemoral socket featuring a motorized cable‐driven system and a sensorized liner, designed to adapt to changes in residual limb volume while monitoring interface pressures. Users can seamlessly control the socket in both open‐ and closed‐loop modes via a customized mobile application, enhancing comfort and ...
Linda Paternò +7 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.R‐APEX is a knowledge graph platform developed to investigate how air pollutants such as particularly fine particulate matter (PM2.5) affect human health. By integrating large‐scale biomedical data and using machine learning, it reveals pollutant–gene–disease associations.
Zhixing Zhu +7 more
wiley +1 more source
The Anatomical Record, EarlyView.Abstract Neuroanatomy studies in vertebrates have garnered significant attention in recent years, particularly driven by advancements in computerized tomography imaging techniques. Nonetheless, these advancements remain largely constrained to specific vertebrate groups, notably mammals, birds, and fish, leaving studies in reptiles at an incipient stage.
Giordanna Issa Lucas, Angele Martins
wiley +1 more source
Animal Research and One Health, EarlyView.The experimental framework of the study encompasses sample collection, single‐cell data analysis, and experimental validation. Abstract Understanding differences in chromatin state and changes in gene regulatory landscape of placode (Pc) and dermal condensate are crucial for decoding hair follicle (HF) morphogenesis programs.
Fang Li +5 more
wiley +1 more source
Journal of the Association for Information Science and Technology, EarlyView.Abstract There has been a notable increase in bibliometric research studying gender in academia. This narrative review aims to organize and synthesize this extensive body of work to uncover new insights into gender disparities in science. We begin by analyzing key methodological elements, including gender assignment techniques, units of analysis, and ...
Elvira González‐Salmón +2 more
wiley +1 more source