Results 101 to 110 of about 41,300 (164)

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Monocyte Transcriptional Reprogramming Explains Refractory In-Stent Restenosis. [PDF]

JACC Basic Transl Sci
Bednarek J, Ibla J, Thorp EB.
europepmc   +1 more source

A Model Based Systems Engineering Framework for Digital Twins in Medical Device Innovation

Systems Engineering, EarlyView.
ABSTRACT Medical device development remains constrained by development processes centered largely in the physical domain. These methods limited early understanding of system behavior and prolonged timelines relative to other innovation pathways. Such limitations increase prototype cycle duration and the number of iterations required to resolve design ...
Tanguy René Pinol, Leon Hugh Prentice, Kate Fox, Toh Yen Pang   +3 more
wiley   +1 more source

Core transcriptional regulatory circuitry identified from patient-derived tumor cells provides a specific vulnerability for rhabdomyosarcoma. [PDF]

Cell Death Dis
Liu S, He Z, Chen X, Tang Y, He M, Zhang L, Xu W, Wang J, Tao T.   +8 more
europepmc   +1 more source

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source

Polysaccharides from Er Chen Decoction: gastrointestinal fate, gut microbiota modulation and metabolomics. [PDF]

Front Microbiol
Liu YJ, Wang ZK, Yue LT, Qiao D, Deng QL, Chang XY, Liu T, Hu MB.   +7 more
europepmc   +1 more source

Distinct Gene Expression Profiles of Ara h 2‐Specific B Cells in Desensitization and Tolerance During Peanut Oral Immunotherapy

Allergy, EarlyView.
Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider, Juan‐Felipe López, Huseyn Babayev, Willem van de Veen, Minglin Yang, Cezmi A. Akdis, Kari Nadeau, Carolyn H. Baloh, Stacie M. Jones, Lisa M. Wheatley, Mübeccel Akdis, IMPACT, Amy M. Scurlock, D. Pesek, Joy Laurienzo‐Panza, Marshall Plaut, A. Wesley Burks, Edwin H. Kim, Mike Kulis, Anna Nowak‐Wegrzyn, Hugh A. Sampson, Julie Wang, Robert A. Wood, Sharon Chinthrajah, Robert Sayantani B. Sindher, Jacqueline Johnson, Katharine Spain, Denise C. Babineau, Hyunsook Chin, Rachel Yan, Don Whitehouse, Michelle L. Sever, Srinath Sanda, David Larson, Tielin Qin, Gina Marchesini, Kavitha Gilroy, Sylvia Posso, Sabrina Skiba, Thien‐Son Nguyen, Adam Wojno, Tuan Nguyen, Vivian Gersuk, Quynh‐Anh Nguyen, Jessica Garber, Kimberly O'Brien, Brandon Larson, C. Cousens‐Jacobs, Alex Hu   +48 more
wiley   +1 more source

Ubiquitin receptor-mediated, ubiquitin-independent targeted protein degradation via 26<i>S</i> proteasomes. [PDF]

Sci Adv
Park SH, Jang Y, Lee SY, Kim E, Jeong D, Byun I, Kim J, Yang J, Lee CH, Han D, Nam JH, Lee MJ.   +11 more
europepmc   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Integrative Multi-omics and Machine Learning Reveal the Therapeutic Mechanisms of Juanyu-Xiaozhi Formula in Metabolic Dysfunction-associated Steatotic Liver Disease and Hepatic Fibrosis via the AP-1/PPARγ/SCD1 Axis. [PDF]

J Clin Transl Hepatol
Jin Z, Huang Y, Zeng C, Zhang Y, Qiu Y, Yang Y, Liu H.   +6 more
europepmc   +1 more source