Results 41 to 50 of about 32,933 (169)

Real‐world use of adjunctive perampanel for focal‐onset seizures in Italy: A mirroring clinical practice study of perampanel in adults and adolescents (AMPA)

Epilepsia Open, EarlyView.
Abstract Objective The AMPA study (Study 501; NCT04257604) was a multicenter, prospective, 12‐month observational study in Italy that evaluated the effectiveness and safety of adjunctive perampanel in patients with focal‐onset seizures (FOS), with or without focal to bilateral tonic–clonic seizures (FBTCS).
Alfredo D'Aniello, Anna Teresa Giallonardo, Paolo Tinuper, Oriano Mecarelli, Umberto Aguglia, Giovanni Assenza, Antonio Gambardella, Maria Paola Canevini, Renato Scifo, Stefano Meletti, Valentina De Giorgis, Enrica Bonanni, Roberto Michelucci, Caterina Cerminara, Antonino Romeo, Federico Vigevano, Francesca Felicia Operto, Luciana Tramacere, Giancarlo Di Gennaro, Alfonso Iudice on behalf of the AMPA Study group, Leock Y. Ngo, Anna Patten, Anna Lisa Gentile, Andrea Pecori, Samantha Goldman   +24 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Instant Intraoperative Histopathological Assessment of Fresh Parathyroid Tissue: Higher Harmonic Generation Microscopy as a Potential Alternative to Frozen Section

Head &Neck, EarlyView.
ABSTRACT Background Hypoparathyroidism is a complication associated with significant morbidity and results from inadvertent removal of the parathyroid during thyroid surgery. Therefore, intra‐operative identification of parathyroid tissue is essential to minimize the risk of hypoparathyroidism.
P. M. Rodriguez Schaap, S. van den Bosch, S. Spies, S. van Eeden, E. J. M. Nieveen van Dijkum, M. L. Groot, A. F. Engelsman   +6 more
wiley   +1 more source

Clinical features and surgical options of obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome: A systematic review and a meta‐analysis of prevalence

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background OHVIRA syndrome, a urogenital malformation, lacks standardized management. Narrative reviews exist, but there is no a comprehensive meta‐analysis. Objectives The aim of this first systematic review and meta‐analysis is to evaluate the current literature and inform management strategies.
Emma Bonetti, Gloria Anderson, Simona Duranti, Federico Ferrari, Franco Odicino, Antonia Testa, Francesco Fanfani, Giovanni Scambia, Ursula Catena   +8 more
wiley   +1 more source

Microbiota humanization drives human‐like metabolic and immune transcriptomic shifts in pigs

iMetaOmics, EarlyView.
This study successfully established gut microbiota‐humanized pigs, achieved human‐like remodeling of the serum metabolome, and uncovered transcriptional alterations in immune cell subsets. These findings advance our understanding of how human gastrointestinal microorganisms affect host metabolism and the immune function in a porcine model.
Zhaoqi Zhang, Yanan Xu, Kun Pang, Changhong Wu, Chenxu Zhao, Tong Lei, Jiayu Zhang, Tang Hai, Fangqing Zhao, Yong Zhao   +9 more
wiley   +1 more source

Nanomaterials for promoting axon regeneration after spinal cord injury: Mechanisms and prospects

Interdisciplinary Medicine, EarlyView.
The effects of clinical therapies for spinal cord injury (SCI) are greatly limited due to poor axon regeneration. This review systematically discusses the ability of nanomaterials (NMs) to treat SCI and the mechanism underlying their therapeutic effects. The properties of NMs that are conducive to axon regeneration after SCI are outlined.
Jia Liu, Zhendong Huang, Xiner Tan, Wei Du, Ziyang Wang, Xinru Zhou, Hao Pan, Lili Chen, Yiyuan Kang, Longquan Shao   +9 more
wiley   +1 more source

Prominent Chiari Network as a Cause of Cyanosis in Infants: A Case Report and Implications for Pediatric Cardiology Practice

Journal of Clinical Ultrasound, EarlyView.
A prominent Chiari network can cause cyanosis in infants by inducing a positional right‐to‐left atrial shunt. Accurate diagnosis enabled conservative management, delaying surgery until optimal conditions. This case emphasizes the importance of echocardiographic evaluation in differentiating cyanosis mechanisms to guide appropriate treatment in ...
Carmen Rodríguez‐Barrios, Irene Gutierrez‐Rosa, Moises Rodriguez‐Gonzalez   +2 more
wiley   +1 more source

Metformin reverses periodontal destruction caused by experimental periodontitis by inhibiting interleukin‐1β activity

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis is a destructive disease that affects periodontal tissue. While current research focuses on disease management, research on tissue repair remains limited. Metformin, a first‐line medication for diabetes treatment, has positive effects on bone health in nondiabetic patients.
Zhao Wang, Ju Han Song, Jung‐Woo Kim, Seung‐Hee Kwon, Xianyu Piao, Sin‐Hye Oh, Suk‐Gyun Park, Sun‐Hun Kim, Je‐Hwang Ryu, Ok‐Su Kim, Jeong‐Tae Koh   +10 more
wiley   +1 more source

ESPGHAN/NASPGHAN guidelines for treatment of irritable bowel syndrome and functional abdominal pain‐not otherwise specified in children aged 4–18 years

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Abdominal pain related disorders of gut–brain interaction (AP‐DGBIs) such as irritable bowel syndrome (IBS) and functional abdominal pain‐not otherwise specified (FAP) are common conditions in children, significantly impacting quality of life.
Jip Groen, Morris Gordon, Ashish Chogle, Marc Benninga, Rachel Borlack, Osvaldo Borrelli, Anil Darbari, Jernej Dolinsek, Julie Khlevner, Carlo Di Lorenzo, Hannibal Person, Rinarani Sanghavi, Julie Snyder, Nikhil Thapar, Arine Vlieger, Vasiliki Sinopoulou, Merit Tabbers, Miguel Saps   +17 more
wiley   +1 more source

Effects of microbiota‐based interventions on depression and anxiety in children and adolescents—A systematic review

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract This study aims to systematically review evidence on gut microbiota‐based interventions for reducing depression‐ and anxiety‐like symptoms in children and adolescents with autism spectrum disorder, irritable bowel syndrome, Prader‐Willi syndrome, below‐average literacy skills or anorexia nervosa, where some individuals may exhibit indicators ...
Jiayu Hu, Yan Zhang, Chuwen Liu, Antigone Gkaravella, Jinyue Yu   +4 more
wiley   +1 more source