Results 71 to 80 of about 32,170 (168)

Development and validity of type II sulcus vocalis in excised canine larynx

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
Abstract Objectives This study aims to develop a sulcus vocalis model in the excised canine larynx and to investigate the validity of the model. Methods Type II sulcus vocalis was created by continuous intradermal suture in six excised canine larynges.
Ting Gong, Peng‐Cheng Yu, Chao Xue, An‐Rong Sun, Yi Zhang, Rui Fang, Bing‐Hua Zhu   +6 more
wiley   +1 more source

Network expression analysis identifies and experimentally validates the involvement of Fosb in acute kidney injury

FASEB BioAdvances, Volume 7, Issue 4, April 2025.
In this study, we used bioinformatics and in vitro and in vivo validations to discover the close association of Fosb with AKI, which was significantly upregulated in AKI. Furthermore, Fosb promoted apoptosis through AP‐1 signaling pathway‐mediated inflammatory responses in renal tubular epithelial cells, suggesting that it has the potential to be a ...
Xiaoyan Tang, Changqiong Shen, Chunqiu Liu, Jianya Gao   +3 more
wiley   +1 more source

Coculture of Bifidobacterium bifidum G9‐1 With Butyrate‐Producing Bacteria Promotes Butyrate Production

Microbiology and Immunology, EarlyView.
ABSTRACT Supplementation with Bifidobacterium bifidum G9‐1 (BBG9‐1) has been established to enhance the production of butyrate, a short‐chain fatty acid (SCFA) known for its beneficial effects in alleviating constipation. We hypothesized that BBG9‐1 alters gut microbiota such that bacteria that produce butyric acid from lactate and acetate become more ...
Haruka Yokota, Yoshiki Tanaka, Hiroshi Ohno   +2 more
wiley   +1 more source

Tissue‐specific methylomic responses to a lifestyle intervention in older adults associate with metabolic and physiological health improvements

Aging Cell, Volume 24, Issue 4, April 2025.
Diet and physical activity influence immunometabolic health across the lifespan, and DNA methylation may mediate a part of these effects. The Growing Old Together (GOTO) study, a 13‐week lifestyle intervention in older adults, revealed epigenetic changes in muscle, adipose, and blood at hundreds of CpGs, linking these to differential gene expression ...
Lucy Sinke, Marian Beekman, Yotam Raz, Thies Gehrmann, Ioannis Moustakas, Alexis Boulinguiez, Nico Lakenberg, Eka Suchiman, Fatih A. Bogaards, Daniele Bizzarri, Erik B. van den Akker, Melanie Waldenberger, Gillian Butler‐Browne, Capucine Trollet, C. P. G. M. de Groot, Bastiaan T. Heijmans, P. Eline Slagboom   +16 more
wiley   +1 more source

The impact of 60 days of ‐6° head down tilt bed rest on mitochondrial content, respiration and regulators of mitochondrial dynamics

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Reductions in skeletal muscle mitochondrial respiration following 60 days of bed rest explained by a decrease in mitochondrial content, but resulting in an increase in OPA1 and Drp1 mediated mitochondrial fission. Abstract It is unclear how skeletal muscle metabolism and mitochondrial function adapt to long duration bed rest and ...
John Noone, Anthony Damiot, Helena Kenny, Isabelle Chery, Alexandre Zahariev, Sylvie Normand, François Crampes, Isabelle de Glisezinski, Keith D. Rochfort, Claire Laurens, Marie‐Pierre Bareille, Chantal Simon, Audrey Bergouignan, Stéphane Blanc, Donal J. O'Gorman   +14 more
wiley   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Aging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano   +24 more
wiley   +1 more source

GluR2 overexpression in ACC glutamatergic neurons alleviates cancer-induced bone pain in rats. [PDF]

Mol Med
Ba F, Wei J, Feng QY, Yu CY, Song MX, Hu S, Xu GY, Zhang HL, Jiang GQ.   +8 more
europepmc   +1 more source

Pyrroloquinoline Quinone Reprograms the Single‐Cell Landscape of Immune Aging in Hematopoietic Immune System

Aging Cell, EarlyView.
This study demonstrates that aging induces oxidative stress and inflammation in the hematopoietic immune system, resulting in immune homeostasis dysfunction, including alterations in B cells and hematopoietic stem cells, senescent cells (SnCs) accumulation, and senescence‐associated secretory phenotypes (SASPs) production. Notably, the study highlights
Xiuxing Liu, Chun Zhang, Jianjie Lv, Yidan Liu, Chenyang Gu, Yuehan Gao, Wen Ding, Hui Chen, Nanwei Xu, Hongbin Yin, Wenru Su, Zhuping Xu   +11 more
wiley   +1 more source

Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course. [PDF]

Circ Genom Precis Med
Urbut SM, Cho SMJ, Paruchuri K, Truong B, Haidermota S, Peloso GM, Hornsby WE, Philippakis A, Fahed AC, Natarajan P.   +9 more
europepmc   +1 more source

Regulation of the MAPK/ERK Pathway by miRNA‐27b in Gastric Cancer: Diagnostic Implications and Therapeutic Potential of Aloin

Asia-Pacific Journal of Clinical Oncology, EarlyView.
ABSTRACT Background Globally, gastric cancer (GC) ranks as the fourth most deadly and fifth most prevalent kind of cancer. Appropriate treatment methods, precise etiology, and molecular processes of GC are still unclear. Methods In silico and quantitative real‐time reverse transcription polymerase chain reaction (qRT‐PCR)‐based expression of miRNA‐27b ...
Yang Dehuo, Wang Ying, Cao Lin
wiley   +1 more source