Results 51 to 60 of about 3,808 (149)

R‐APEX: A Knowledge Graph–Based Platform for the Elucidation of the Toxicological Mechanisms of Ambient Particulate Matter

open access: yesAdvanced Intelligent Systems, EarlyView.
R‐APEX is a knowledge graph platform developed to investigate how air pollutants such as particularly fine particulate matter (PM2.5) affect human health. By integrating large‐scale biomedical data and using machine learning, it reveals pollutant–gene–disease associations.
Zhixing Zhu   +7 more
wiley   +1 more source

Inside the head of Crotalus durissus LINNAEUS, 1758 (Serpentes, Viperidae, Crotalinae): Macroscopic description of the brain with ontogenetic insights

open access: yesThe Anatomical Record, EarlyView.
Abstract Neuroanatomy studies in vertebrates have garnered significant attention in recent years, particularly driven by advancements in computerized tomography imaging techniques. Nonetheless, these advancements remain largely constrained to specific vertebrate groups, notably mammals, birds, and fish, leaving studies in reptiles at an incipient stage.
Giordanna Issa Lucas, Angele Martins
wiley   +1 more source

The woman researcher's tale: A review of bibliometric methods and results for studying gender in science

open access: yesJournal of the Association for Information Science and Technology, EarlyView.
Abstract There has been a notable increase in bibliometric research studying gender in academia. This narrative review aims to organize and synthesize this extensive body of work to uncover new insights into gender disparities in science. We begin by analyzing key methodological elements, including gender assignment techniques, units of analysis, and ...
Elvira González‐Salmón   +2 more
wiley   +1 more source

Female Directors, Family Firms, Climate Talk and Climate Walk: European Evidence

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT Growing attention is attributed to symbolic and substantive climate efforts, labelled as climate talk and walk. Focusing on the European capital market, we study the relationship between board gender diversity, family ownership and different levels of corporate climate activities along the continuum from climate talk to climate walk.
Niklas Bergmann   +2 more
wiley   +1 more source

Mining Thermophile Genomes for New PETases with Exceptional Thermostabilities Using Sequence Similarity Networks

open access: yesChemBioChem, EarlyView.
Targeted genome mining identified thermostable enzymes (PETases) that hydrolyze the commonly used plastic polymer polyethylene terephthalate (PET). Thermostable enzymes are identified from thermophilic microbial sources. Experimental results reveal enzymatic activity on authentic PET films, highlighting potential for industrial application.
Zhenyu Hu   +4 more
wiley   +1 more source

Engineering and Structural Elucidation of a Sac7d‐Derived IgG Fc‐Specific Affitin and Its Application for the Light‐Controlled Affinity Purification of Antibodies

open access: yesChemBioChem, EarlyView.
An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl   +7 more
wiley   +1 more source

SAAP‐148 Oligomerizes into a Hexamer Forming a Hydrophobic Inner Core

open access: yesChemBioChem, EarlyView.
The highly cationic and hydrophobic antimicrobial peptide SAP‐148 effectively eradicates multidrug‐resistant bacteria, persistent cells, and biofilms without inducing resistance. Its efficiency is likely due to its ability to disrupt bacterial membranes as an oligomer, forming a stable alpha‐helical hexameric bundle with three parallel dimers that ...
Aden Hodzic   +15 more
wiley   +1 more source

Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP‐Lyase Function

open access: yesChemistry – A European Journal, EarlyView.
Organocatalytic switches are small molecules that combine active site affinity and a nitrogen‐centered base for catalysis, effectively removing the rate‐determining step of the OGG1 biochemical cascade. Here, we identify a minimal structure and modulate the active nitrogen pKa, enabling the catalysis of ultrafast AP site incisions in a range of pH ...
Mario Kehler   +28 more
wiley   +1 more source

A ketol‐acid reductoisomerase inhibitor that has antituberculosis and herbicidal activity.

open access: yesChemistry – A European Journal, Accepted Article.
Ketol‐acid reductoisomerase (KARI) is a target for the development of new biocidal agents. This is based on its essential role in branched chain amino acid biosynthesis in plants and microorganisms, and its absence in animals. The lack of success in developing KARI inhibitors as biocides may be because the inhibitors assessed to date compete directly ...
Luke William Guddat   +9 more
wiley   +1 more source

Corn cob pyrolysis: A systematic literature review of methods and applications

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Mapping the research landscape of corn cob pyrolysis. Abstractas The agricultural sector is experiencing a surge in waste generation due to population growth, creating an urgent need to convert byproducts into value‐added products. Maize (Zea mays L.), a leading global crop, produces significant byproducts, such as corn cob, which are often undervalued.
Vilmar Steffen   +5 more
wiley   +1 more source

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