Results 41 to 50 of about 29,802 (167)
ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy
Advanced Science, EarlyView.Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie +11 more
wiley +1 more source
Advanced Science, EarlyView.The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park +9 more
wiley +1 more source
Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain
Advanced Science, EarlyView.Ce‐UiO‐66‐Bupivacaine (CUB) demonstrates triple therapeutic innovation: 1) Sustained analgesia with ROS scavenging synergistically resolves neuropathic pain; 2) Microglia/astrocyte polarization switch reprograms the pro‐regenerative immune microenvironment; 3) CGRP‐TSP‐1 axis activation couples inflammation suppression to axon regeneration, defining a ...
Yue Wang +9 more
wiley +1 more source
Advanced Science, EarlyView.A healthcare toilet system is introduced to passively measure defecation behavior. Real‐time data on stool dropping duration, thickness, and a newly defined “eu‐tenesmus” interval show correlations with stool form and gender differences. Results from 45 defecation events reveal a promising method for comprehensive defecation analysis.
Zhiquan Song +16 more
wiley +1 more source
Advanced Science, EarlyView.This study introduces a novel transdermal delivery system of molecular hydrogen for postoperative pain relief and wound healing. This system utilizes sustained‐release photothermal microneedles to integrate hydrogen‐releasing nanoparticles and temperature‐responsive microspheres, achieving acid‐responsive hydrogen release and controlled drug release ...
Aining Zhang +8 more
wiley +1 more source
Advanced Science, EarlyView.Scalable nylon fabrics with bioinspired light‐trapping nanostructures and 84.6% intrinsic photothermal conversion efficiency are developed for solar desalination. The Janus evaporator shows high evaporation rate of 3.84 kg m−2 h−1 and long‐term stability in seawater, offering a cost‐effective solution for solar desalination.
Mingqing Yu +7 more
wiley +1 more source
Advanced Science, EarlyView.The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu +13 more
wiley +1 more source
Advanced Science, EarlyView.The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He +9 more
wiley +1 more source
BMSC‐NFMC Model for Vascular Regulation and Interface Integration in Osteochondral Regeneration
Advanced Science, EarlyView.A novel strategy for integrated osteochondral tissue regeneration using BMSC‐NFMCs, this study has demonstrated the precise regulation of vascularization and effective interface integration using optimized nanofibrous materials and innovative construction methods.
Qian Zhou +8 more
wiley +1 more source
Advances in Medical Devices for Augmented Acupuncture Therapy
Advanced Science, EarlyView.Traditional acupuncture therapy faces several challenges in clinical applications, such as complex operation procedures and prolonged therapeutic periods. By incorporating physical stimulations and drug delivery technologies, engineered acupuncture needles (EANs) can enhance therapeutic efficacy, improve patient compliance, as well as mitigate ...
Ruisi Cai +7 more
wiley +1 more source