Results 51 to 60 of about 29,802 (167)
Advanced Science, EarlyView.Glioblastoma (GBM) is an aggressive brain cancer that often recurs and resists chemotherapy. This study found that a chemical called PGE2 causes surrounding brain cells (neurons) to become over‐excited, which makes GBM cells resistant to treatment. Researchers developed a new drug, “Compound 11,” which can cross into the brain and effectively block ...
Chih‐Jie Shen +14 more
wiley +1 more source
Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury
Advanced Science, EarlyView.The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He +11 more
wiley +1 more source
Advanced Science, EarlyView.Nanoplastics exposed to defined weathering conditions are systematically investigated as vectors for polycyclic aromatic hydrocarbons (PAHs). This investigation demonstrates significant potential for enhancing PAH uptake and transport in an intestinal membrane model.
Erik B. Schiferle +5 more
wiley +1 more source
Advanced Science, EarlyView.This study performs dual CRISPR screens in pEPSCs. Fitness screening identifies essential genes for viability, while FACS‐based screening uncovers core pluripotency factors. It highlights FOXH1 as a key regulator that maintains the stem cell state through a dual‐action mechanism: preserving pluripotency by enhancing chromatin accessibility and ...
Peng Su +13 more
wiley +1 more source
Highly Crystalline and Oriented Thin Films of Fully Conjugated 3D‐Covalent Organic Frameworks
Angewandte Chemie, EarlyView.This work introduces a fully conjugated, 3D covalent organic framework (COF) based on cyclooctatetrathiophene (COTh); the synthesis employs modulated conditions to achieve thin films with high crystallinity. The COTh‐1P COF shows potential for optoelectronic applications, thanks to its π‐conjugated structure, the preferential film orientation, and ...
Ignacio Munoz‐Alonso +9 more
wiley +2 more sources
High‐Density Flexible Neural Implants with Submicron Feedline Resolution
Advanced Electronic Materials, EarlyView.Optimization of microfabrication methods using optical contact lithography (OCL) and electron beam lithography (EBL) enables the fabrication of 64‐channel, high‐density, parylene‐C‐based intracortical implants with submicron feedlines as narrow as 400 and 50 nm, respectively.
Lina Koschinski +10 more
wiley +1 more source
Angewandte Chemie, EarlyView.Fortification of FeS clusters in Ni─Fe CO dehydrogenase (Carboxydothermus hydrogenoformans) reshapes this anaerobic enzyme into an air‐viable variant through multilayered O2 tunnel sealing. The engineered enzyme retains structural integrity and catalytic efficiency in ambient air, offering a practical solution for industrial CO/CO2 bioconversion ...
Suk Min Kim +9 more
wiley +2 more sources
Annals of Gastroenterological Surgery, EarlyView.The association between BMD reduction during NAC and the worse prognosis remains unknown, although NAC followed by esophagectomy is a standard treatment for advanced ESCC. This study appeared that BMD massive reduction was an independent prognostic factor on OS (HR, 3.30; 95% confidence interval [CI], 1.69–6.55) and RFS (HR, 2.08; 95% CI, 1.19–3.63 ...
Kazuhide Sato +11 more
wiley +1 more source
Angewandte Chemie, EarlyView.N‐alkylated heteroarenes are key structural motifs in bioactive compounds, but their regioselective synthesis via coupling of readily available azoles with haloalkanes remains very challenging. Here, we present a mild biocatalytic approach that proceeds on gram‐scale, is highly chemo‐ and regioselective, offering rapid access to valuable N‐alkylated ...
Felipe Ospina +10 more
wiley +2 more sources
Smart Transfemoral Prosthetic Socket with Motorized Cable‐Driven System
Advanced Intelligent Systems, EarlyView.This study presents an innovative transfemoral socket featuring a motorized cable‐driven system and a sensorized liner, designed to adapt to changes in residual limb volume while monitoring interface pressures. Users can seamlessly control the socket in both open‐ and closed‐loop modes via a customized mobile application, enhancing comfort and ...
Linda Paternò +7 more
wiley +1 more source