Results 121 to 130 of about 513 (219)

A Gene Expression Tumor Signature Optimizing Partial Area‐Under‐the‐Curve (pAUC) to Improve Specificity for Indolent Prostate Cancer

The Prostate, EarlyView.
ABSTRACT Purpose A key clinical challenge in prostate cancer is the identification and validation of biomarkers with high specificity for indolent long‐term outcomes. We applied a novel statistical method to identify tumor transcriptomic biomarkers that optimally predicted patients with low metastatic potential.
Travis A. Gerke, Svitlana Tyekucheva, Konrad H. Stopsack, Christopher J. Sweeney, Rosina T. Lis, Elizabeth N. Westling, Massimo Loda, Meir J. Stampfer, Kathryn L. Penney, Giovanni Parmigiani, Lorelei A. Mucci   +10 more
wiley   +1 more source

Xylooligosaccharide Production From Lignocellulosic Biomass and Their Health Benefits as Prebiotics. [PDF]

Biochem Res Int
Kumari K, Nagar S, Goyal S, Maan S, Chugh V, Kumar V, Kharor N.   +6 more
europepmc   +1 more source

The X‐Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two‐Component Flavin‐Dependent Tryptophan Halogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma, Emily W. Rady, Aravinda J. de Silva, John J. Bellizzi III   +3 more
wiley   +1 more source

Oyster cooking practices in the United States-based restaurants-A survey. [PDF]

PLoS One
Mirmahdi RS, Farzad R, MacIntosh AJ, Havelaar AH, Simonne AH, Montazeri N.   +5 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Challenges and limitations in using bacterial metabolites as immunomodulators. [PDF]

Front Cell Infect Microbiol
Saravanan C, Gopinath NK, Ganesan R, Thirumurugan D.   +3 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Targeting the gut microbiome for type 2 diabetes management: a scoping review of systematic reviews and meta-analyses. [PDF]

Front Endocrinol (Lausanne)
Jiang R, Zheng L, Fang J, Guan Q, Yuan H, Liang J, Zhang J, Han Q, Liu M.   +8 more
europepmc   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Perspectives of stakeholders on post-trial access arrangements in Ethiopia: a qualitative study. [PDF]

Glob Bioeth
Tucho GT, Wangamati CK, Kumsa DM, Bernabe RC.   +3 more
europepmc   +1 more source