Results 81 to 90 of about 420 (120)
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Negative regulation of human c-fos expression by thes retinoblastoma gene product
Nature, 1990Inactivation of the retinoblastoma susceptibility gene (RB-1) has been associated with the aetiology of many types of human cancers, leading to the classification of RB-1 as an anti-oncogene or tumour suppressor gene. Given that the protein product of RB-1 (Rb) has a nuclear localization and DNA-binding activity in vitro, it is possible that Rb ...
P D, Robbins +2 more
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c-jun and c-fos are expressed by human megakaryocytes.
Experimental hematology, 1992Expression of the main nuclear protooncogenes during terminal megakaryocyte (MK) differentiation is poorly understood. Because previous results have suggested that c-fos and c-jun protooncogenes are expressed in human leukemic cell lines induced to undergo megakaryocytic differentiation, we have analyzed the expression of these two protooncogenes in ...
M A, Mouthon +4 more
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Expression of c-fos in human and murine multidrug-resistant cells.
Molecular Pharmacology, 1992In both mouse sarcoma 180 and human KB cells selected for the multiple drug resistance (MDR) phenotype, there is an elevation in the steady state mRNA level of c-fos. There is no detectable gene amplification for c-fos, nor is there any significant change in the rate of mRNA transcription or degradation, suggesting that other factors are responsible ...
A, Bhushan +3 more
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Resistance of human fibroblasts to c-fos mediated transformation.
Oncogene, 1993Overexpression of the proto-oncogene c-fos induces transformation of primary avian and established rodent mesenchymal cells and tumor development in transgenic mice. As overexpression of Fos was also found in several human tumors of mesenchymal origin, we were interested whether c-fos is a transforming protein for human cells.
M, Alt, R, Grassmann
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Expression of c‐sis and c‐fos genes in human meningiomas and neurinomas
International Journal of Cancer, 1992AbstractThe HindIII c‐sis RFLP was analyzed in constitutional and tumor DNAs of 19 meningioma patients. Loss of a c‐sis allele (allele 1 in all cases) was observed in 6 out of 10 tumors from heterozygous patients. No alteration in the structure or dosage of the c‐sis gene was detected in any tumor sample.
P. Riva, L. Larizza
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The influence fo traumatic splenectomy on the volume of human platelets.
Surgery, gynecology & obstetrics, 1978A rise in the blood platelet count and volume occurred in 11 patients following traumatic splenectomy. The pattern of the volume distribution, however, remained unchanged. This indicates an increased rate of platelet production, with the newly formed cells substantially larger than their preoperative counterparts, and can be interpreted in terms of a ...
N, Laufer +3 more
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c-fos Protein-like immunoreactivity in cultured human glial cells
Neuroscience Research, 1990The expression of the c-fos protein(s) in cultured glial cells of the human brain and sympathetic ganglia was studied immunocytochemically using an antibody to a synthetic fragment of the c-fos protein (M-peptide). GFAP (glial fibrillary acidic protein) and S-100 antibodies were used as glial cell markers.
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Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation
Cell, 1985The differentiation into macrophages of the monocytic cell line U-937 or the monomyelocytic cell line HL-60 induced by phorbol esters is accompanied by a rapid induction of the expression of the proto-oncogene c-fos. Maximal levels of c-fos gene transcripts accumulate within 20-30 min following induction.
R L, Mitchell +3 more
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c-Fos activation and intermale aggression in rats selected for behavior toward humans
Behavioural Brain Research, 2013Tame and aggressive rat lines were created during the long-term selection of Norway rats for elimination and enhancement of aggressiveness toward humans, respectively. Our previous experiments have demonstrated that selection for the elimination of defensive aggression toward humans is associated with attenuated intraspecific intermale aggression ...
Maria Yu, Konoshenko +2 more
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C-FOS expression in the subnucleus gelatinosus of the human nucleus tractus solitarii.
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia, 2004The dorsal portion of the nucleus tractus solitarii (NTS) shows selective dendritic lesions in adults who died after an episode of acute heart failure, suggesting excitotoxic glutamate-induced neuronal death. Cerebral hypoxia and/or ischaemia also produce hyperexpression of specific genes (c-fos, c-jun) which may be involved, in vulnerable districts ...
PORZIONATO, ANDREA +4 more
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