Results 61 to 70 of about 22,506 (169)

Effectiveness of Organized Strategies to Enhance Access to Preventive Oral Cancer Screening Among High‐Risk Individuals in Brazil: A Randomized Clinical Trial in Primary Care

International Journal of Cancer, EarlyView.
This randomized clinical trial evaluated the performance of organized risk‐based strategies to expand access to cancer preventive oral examination among vulnerable populations within the public health system of Rio de Janeiro, Brazil. Compared with an opportunistic approach, the organized invitation‐based oral cancer screening approaches systematically
Marcia Frias Pinto Marinho, Keith Bullia da Fonseca Simas, Patrícia Vinas Heras, Claudia Aparecida Serra da Cruz, Amanda Martins dos Santos Bessa, Mário José Romãnach, Aline Corrêa Abrahão, Maria Augusta Visconti, Michelle Agostini   +8 more
wiley   +1 more source

Novel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice. [PDF]

J Cachexia Sarcopenia Muscle
Hunt JE, Lund C, Chen B, Diaz AR, Dmytriyeva O, Marcotorchino J, Löbner K, Mörl K, Andersen NR, Ogueboule ZKJ, Frank E, Stöhr J, Meseguer D, Panajotova V, Roux J, Clemmensen C, Sylow L, Schneeberger M, Beck-Sickinger AG, Pedersen SL, Fosgerau K.   +20 more
europepmc   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

1,5-Anhydro-D-Mannitol Is a Potentially Low-Energy Carbohydrate: A Dual-Model Approach in Rats and a Randomized, Three-Way Crossover Trial in Humans. [PDF]

Nutrients
Tanabe K, Tanaka I, Hayashi H, Yoshinaga K, Nakamura S.   +4 more
europepmc   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Substance P-expressing neurons in the hypothalamic paraventricular nucleus mediate chronic cough hypersensitivity via the hypothalamus-airway neural pathway. [PDF]

Front Neurosci
Zhang X, Chen J, Lin C, Xiao T, Wu B, He F.   +5 more
europepmc   +1 more source

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Custom foot orthoses for chronic metatarsalgia: Study protocol for a participant- and assessor-blinded superiority randomized controlled trial. [PDF]

PLoS One
Payen Schalkens E, Acien M, Marchand AA, Isabelle PL, Abboud J, Moisan G.   +5 more
europepmc   +1 more source

COL1A1+ Epithelial Cells Orchestrate VEGFA‐VEGFR Signaling in Endometritis Revealed by Single‐Cell Analysis

Journal of Clinical Laboratory Analysis, EarlyView.
Single‐cell RNA‐seq of normal and endometritis endometrium shows reduced epithelial cells and fate divergence toward ferroptosis or ribosome/antigen‐presentation programs. COL1A1+ epithelial cells act as an AP‐1–driven hub that enhances VEGFA–VEGFR signaling and remodels the vascular microenvironment.
Chengzi Tian, Zaiyi Li
wiley   +1 more source

Prenatal cigarette exposure induces offspring hyperactivity and affective alterations via gut -brain axis metabolic dysregulation and region-specific neuronal hyperactivation. [PDF]

Brain Behav Immun Health
Zhang TL, Qiu W, Shi XY, Gou YH, Shi YR, Bi YJ, Wang Y, Zhang HD.   +7 more
europepmc   +1 more source