Results 71 to 80 of about 7,945 (167)

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Macroscopic, Histological and Ultrastructural Features of the Tongue of the Anatolian Wild Boar (Sus scrofa libycus)

Microscopy Research and Technique, EarlyView.
Integrated macroscopic, histological, and ultrastructural analyses revealed five distinct lingual papillae types (filiform, fungiform, conical, foliate, and vallate) in the Anatolian wild boar (Sus scrofa libycus). Mechanical papillae showed marked structural specialization, while gustatory papillae exhibited region‐specific distribution of taste buds.
Fatma Işbilir, Banu Kandil, Muhammed Zahid Atli, İhsan Işbilir, Barış Can Güzel   +4 more
wiley   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Combined Effects of Puerarin and Adipose‐Derived Stem Cells on Alveolar Bone Preservation and Inflammation Control in Periodontitis Through p38MAPK Modulation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley   +1 more source

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

Hunting motivations, behaviour and forest access: Characterising wildlife hunting practices in a multi‐ethnic, forested landscape of Brunei Darussalam, Southeast Asia

People and Nature, EarlyView.
Abstract Unsustainable hunting practices can alter population dynamics, driving biodiversity declines, which leads to ‘empty forests’. Understanding hunting behaviour, including motivations for hunting and relationships with market drivers, and access to hunting grounds are important to develop affirmative policies to stem biodiversity loss.
Natasha L. M. Mannion, Rachel Gaulton, Maria Erica Jamil, Marion Pfeifer, Johan Willem Ferry Slik, Stephen G. Willis, F. Merlin Franco   +6 more
wiley   +1 more source

Fmoc-DDT@Fos hydrogel mitigates temporomandibular joint osteoarthritis through regulating macrophage reprogramming and ferroptosis. [PDF]

Mater Today Bio
Zhang Y, Zhang D, Yue X, Xu Q, Bu L, Lu J, Yang C, Shen P, Zheng J.   +8 more
europepmc   +1 more source

Engaging the public in plant science: Communication facilitators and barriers of scaling up a citizen science campaign

People and Nature, EarlyView.
Abstract Volunteers have been involved in nature observations for decades through citizen science initiatives, providing large data sets as well as problem identification that allow a more complete understanding of many natural phenomena. Although communication is a core component in citizen science, the key factors that determine its effectiveness in ...
Kristiina Gibson, Monika Suškevičs, Baiba Prūse, Marta Barberis, Sara A. O. Cousins, Živa Fišer, Margaux Julien, Marianne Kivastik, Marcin Klisz, Attila Lengyel, Zuzana Münzbergová, Radosław Puchałka, Iris Reinula, Froukje Rienks, Julie Koch Sheard, Viktor Siverin, Bojana Stojanova, Sabrina Träger, Tsipe Aavik   +18 more
wiley   +1 more source

Microglia alter autonomic nucleus neuronal activation after peripheral cytokine challenge. [PDF]

Am J Physiol Cell Physiol
Castellanos EA, Schwerdtfeger LA, Smith BN, Tobet SA.   +3 more
europepmc   +1 more source

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, EarlyView.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source