Results 121 to 130 of about 5,433 (168)

Computer-Aided Diagnosis of Equine Pharyngeal Lymphoid Hyperplasia Using the Object Detection-Based Processing Technique of Digital Endoscopic Images. [PDF]

Animals (Basel)
Kozłowska N, Borowska M, Jasiński T, Wierzbicka M, Domino M.   +4 more
europepmc   +1 more source

Made in the shade: Leaf responses of native wildflowers to single‐axis photovoltaic solar energy

PLANTS, PEOPLE, PLANET, EarlyView.
As solar energy expands globally, balancing renewable power generation with biodiversity and ecosystem health has become an urgent challenge. This study investigated how native wildflowers respond at leaf level to the unique microclimates created by rotating solar panels in California's Central Valley.
Yudi Li, Troy Magney, Alona Armstrong, Rebecca R. Hernandez   +3 more
wiley   +1 more source

Rare regulatory mutations disrupt mesenchymal molecular programs driving endocardial cushion formation in bicuspid aortic valve. [PDF]

Nat Commun
Zhigulev A, Buyan A, Lázár E, Gryzunov N, Lång K, Mauron R, Nozdrin V, Spalinskas R, Pradhananga S, Petersson Sjögren M, Schwochow D, Franco-Cereceda A, Lundeberg J, Kulakovskiy IV, Eriksson P, Björck HM, Sahlén P.   +16 more
europepmc   +1 more source

Precision environmental medicine: Integrated multi‐exposure transcriptomics for shared molecular networks in COPD pathogenesis in response to environmental exposure

Precision Medical Sciences, EarlyView.
This integrated systems biology study of 2847 exposure‐related genes identifies a conserved 647‐gene core and CYP1B1 hub across cigarette smoke, ozone, and PM2.5. Three key pathways converge, enabling computational repurposing of 15 drug candidates (e.g., NRF2 activators) for environmentally induced COPD.
Fakher Rahim, Gürler Akpinar, Kenesh Dzhusupov   +2 more
wiley   +1 more source

Research on the Frost-Heave Feature of Roadbed Soil Reinforced by Polyurethane Using Distributed Fiber-Optic Sensing. [PDF]

Polymers (Basel)
Li J, Cao D.
europepmc   +1 more source

The X‐Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two‐Component Flavin‐Dependent Tryptophan Halogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma, Emily W. Rady, Aravinda J. de Silva, John J. Bellizzi III   +3 more
wiley   +1 more source

Generation and characterisation of a humanised GLP-1 receptor mouse model for translational drug development. [PDF]

EBioMedicine
Sonne N, Roque M, Zachariassen LF, Porsgaard T, Pors SE, Cavalera M, Jones C, Osborn O, Thorbek DD, Riis ML, Feigh M, Quinn K, Gaidarov I, Anthony T, Hansen HH, Tozzi M.   +15 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Optogenetic-induced α-synuclein accumulation reveals early synaptic dysfunction in experimental models of Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Rodriguez-Aller R, Romero-Quineche B, Morissette M, Sheta R, Di Paolo T, Saghatelyan A, Oueslati A.   +6 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source