Results 151 to 160 of about 483 (171)

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review. [PDF]

Dent J (Basel)
Saha S, Sachivkina N, Lenchenko E, Pilshchikova O, Muraev A.   +4 more
europepmc   +1 more source

MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis

Cancer Science, EarlyView.
MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei, Xiangyu Liu, Shimin Hu, Xiaodie Shen, Yingli Liu, Xinxin Qin, Ye Zhou, Jianqi Zheng, Bingke Tian, Jingfang Hong, Yongxia Song, Di Wang, Linlin Peng, Jinxia Ding, Fang Wang, Hui Zhang, Shihao Zhang, Huan Qiu   +17 more
wiley   +1 more source

Smoking and osteoimmunology: Understanding the interplay between bone metabolism and immune homeostasis. [PDF]

J Orthop Translat
Xie G, Huang C, Jiang S, Li H, Gao Y, Zhang T, Zhang Q, Pavel V, Rahmati M, Li Y.   +9 more
europepmc   +1 more source

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source

Targeting ApoE-KCC2 Signaling Rescues GABAergic Synaptic Dysfunction and Depression-like Behaviors in Mice. [PDF]

Research (Wash D C)
Xu C, Liu J, Guo M, Wang J, Bai X, Zhang C, Luan X, Pei H, Liu H, Lv X, Ye X, Tang B, Chen M.   +12 more
europepmc   +1 more source

Exercise-conditioned extracellular vesicles in Alzheimer's disease: a multi-organ signaling network linking peripheral adaptation to brain pathology. [PDF]

Front Immunol
Zhang R, Chen K.
europepmc   +1 more source

In-situ, real-time monitoring of thermo-mechanical properties of biological tissues undergoing laser heating and ablation. [PDF]

Biomed Opt Express
Kurbanova B, Alisherov S, Ashikbayeva Z, Katrenova Z, Sametova A, Gaipov A, Molardi C, Blanc W, Tosi D, Utegulov Z.   +9 more
europepmc   +1 more source

Putting performance bias to the front-lower side of the hole on steep slopes: Differences in strategies and movements between professional and amateur golfers. [PDF]

PLoS One
Hasegawa Y, Okada A, Fujii K.
europepmc   +1 more source

Medical humanities: to cure sometimes, to relieve often, to comfort always

Medical Journal of Australia, 2005
Jill Gordon
exaly