Results 61 to 70 of about 7,500 (212)
Advanced Science, EarlyView.Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang +8 more
wiley +1 more source
Matrix Stiffness Induces Endothelial Network Senescence
Advanced Science, EarlyView.Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song +6 more
wiley +1 more source
, 2017 This is a presentation of the longitu- dinal and multidisciplinary research program Malmö Youth Sport Study (MYSS), which is an independent continuation of the Bunke o project.
Peterson, Tomas +13 more
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Localizing Brain Regions Associated with Female Mate Preference Behavior in a Swordtail
, 2012 Female mate choice behavior is a critical component of sexual selection, yet identifying the neural basis of this behavior is largely unresolved. Previous studies have implicated sensory processing and hypothalamic brain regions during female mate choice
Mary E. Ramsey (116452) +15 more
core +2 more sources
Open Access Publishing: A Literature Review [PDF]
, 2014 Within the context of the Centre for Copyright and New Business Models in the Creative Economy (CREATe) research scope, this literature review investigates the current trends, advantages, disadvantages, problems and solutions, opportunities and barriers ...
Frosio, Giancarlo, Derclaye, Estelle
core +1 more source
ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief
Advanced Science, EarlyView.ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng +19 more
wiley +1 more source
Scholarly Research Funding, The National Institutes of Health, and Mandatory Open Access (OA)
, 2009 This is an exploration of the efforts to promote open access (OA) to publicly funded scholarly research, specifically those projects supported by the National Institutes of Health (NIH), the largest supporter of medical research in the world.
Jeung, Michael
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HARMFUL ALGAL BLOOM STRESSORS ALTER BEHAVIOR AND BRAIN ACTIVITY IN THE KILLIFISH, FUNDULUS HETEROCLITUS. [PDF]
, 2005 Harmful algal bloom (HAB) events are increasing in severity and frequency worldwide, and are known to severely impact fish populations. Impacts of HABs on fish, as well as other organisms, occur through toxic and physical stress. Behavioral and central
Salierno, James D
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Asia-Pacific Journal of Chemical Engineering, EarlyView.ABSTRACT Driven by the energy crisis and carbon neutrality goals, high‐efficiency heat exchange equipment has become a core demand in the industrial sector. The spiral grooved double‐pipe heat exchanger exhibits significant heat transfer enhancement advantages, yet it requires balancing heat transfer efficiency and pressure loss.
Yueyun Yang, Wei Li, Xiuzhi Xi, Neng Gao
wiley +1 more source
Avaliação dos substratos neurais do efeito ansiogênico da substância P [PDF]
, 2000 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Curso de Pós-Graduação em FarmacologiaO presente trabalho investigou o substrato neuroanatômico e o envolvimento dos receptores taquicinérgicos NK1 e NK2 na ...
Gavioli, Elaine Cristina
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