A Model Based Systems Engineering Framework for Digital Twins in Medical Device Innovation
Systems Engineering, EarlyView.ABSTRACT Medical device development remains constrained by development processes centered largely in the physical domain. These methods limited early understanding of system behavior and prolonged timelines relative to other innovation pathways. Such limitations increase prototype cycle duration and the number of iterations required to resolve design ...
Tanguy René Pinol +3 more
wiley +1 more source
Unilateral Biportal Endoscopic en Bloc Resection of the Lumbosacral Ligament Following Bony Release: A Technique Aiming to Reduce Dorsal Root Ganglion Manipulation. [PDF]
J Clin MedLee CY +4 more
europepmc +1 more source
Wildlife Biology, EarlyView.Understanding how prey species tradeoff predation risk and resource acquisition is particularly important for advancing our knowledge of predator–prey relationships. We investigated this by studying the use of concentrated anthropogenic resources, namely supplementary feeding sites, by roe deer Capreolus capreolus before and after grey wolf Canis lupus
Federico Ossi +7 more
wiley +1 more source
Geophysical Monograph Series, Page 137-165., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Konstantin Litasov +3 more
wiley +2 more sources
Activation of Kv7.3 channels in mPFC engram neurons suppresses methamphetamine memory retrieval by reducing excitability and glutamate release in the mPFC-NAc circuit. [PDF]
Cell Mol Life SciHan W +9 more
europepmc +1 more source
Journal of Synchrotron Radiation, EarlyView.A simple fixed‐target protein serial crystallography method combining a grease matrix with a large‐area support film enables stable sample handling, low sample consumption, and high‐resolution room‐temperature structure determination.Serial femtosecond crystallography (SFX) enables structural determination of biological macromolecules at room ...
Michihiro Sugahara +11 more
wiley +1 more source
Oligosaccharide prebiotics in functional foods and therapeutics: innovations and challenges. [PDF]
3 BiotechSandra KS +6 more
europepmc +1 more source
History, EarlyView.Abstract This article offers new perspectives on the relationship between elementary teaching, scientific expertise and the professionalization of the human sciences. Previous scholarship has demonstrated the ready existence of ‘amateur’ science societies in the nineteenth century where cross‐class exchanges were common.
Julia Gustavsson
wiley +1 more source
Attack Repertoires in Outbred Male CD1-Mice Are Associated with Nucleus Accumbens Neuroligin-2. [PDF]
eNeuroGoodwin NL +7 more
europepmc +1 more source
International Journal of Urban and Regional Research, EarlyView.Abstract Foregrounding the role of finance, this article examines the historical production and future trajectory of the urban water crisis in Mombasa. Drawing on archival research and contemporary fieldwork, it traces how principles of full cost recovery—institutionalized during the colonial period and later reworked through postcolonial ...
Joe Williams
wiley +1 more source