Results 151 to 160 of about 3,582,096 (216)

Deletion of Tgf-β1 From CD206⁺ M2 Macrophages Ameliorates Obesity-Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle. [PDF]

J Cachexia Sarcopenia Muscle
Bilal M, Anh LD, Phuong NQ, Khalid S, Nawaz A, Memoona, Aslam MR, Kado T, Watanabe Y, Nishimura A, Igarashi Y, Sharif A, Onogi Y, Wada T, Hayashi R, Hirabayashi K, Yamamoto S, Nakagawa T, Mori H, Usui I, Kato M, Fujisaka S, Tobe K.   +22 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Emerging directions in tauopathy research. [PDF]

Alzheimers Dement
Buée L, Wildsmith KR, Alladi S, Bertucci T, Boche D, Bowles KR, Boxer A, Brummet J, DeVos SL, Diaz K, Dreyer AJ, Duff K, Duran-Aniotz C, Durrant CS, Farrell K, Fontana IC, Franzmeier N, Frost B, Horie K, Kaňovský P, Kao AW, Mahinrad S, Malpetti M, Morris HR, Palleis C, Petrucelli L, Rexach J, Reyderman L, Rommel A, Rowe JB, Sanabria Bohórquez SM, Sato C, Schöll M, Schneider A, de Silva R, Snyder HM, VandeVrede L, Varga AW, Vogel JW, Yeh FL, Yoo AS, Carrillo MC.   +41 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Deciphering optical coupled resonant systems with physics-data co-driven deep neural networks. [PDF]

Light Sci Appl
Liu SY, Zhong HT, Yu XC, Zhang BL, Zhang LY, Xu Y, Zhu NH, Chen JH, Wen HS, Huang SG, Yang DQ.   +10 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Exploring the mechanism of reducing the risk of falls in knee osteoarthritis patients by using Baduanjin based on the functional connection of vestibular network: a study protocol for a randomised controlled trial. [PDF]

BMJ Open
Zhang H, Chen L, Chen J, Zhou X, Wang S, Zhuang Z, Lu Y, Wan Y, Chen S.   +8 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A General Finite Beam on Tensionless Foundation Model for Rail Track Characterization and Evaluation. [PDF]

Sensors (Basel)
Alshallaqi HH, Story BA.
europepmc   +1 more source