Results 131 to 140 of about 420,357 (288)
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Foundation Deposits and Strategies of Place-Making at Tell el-Dab'a/Avaris
Near Eastern Archaeology, 2018 Foundation ceremonies are well known from the Egyptian royal and sacred spheres: They mark the beginning of construction work and ensure the effectiveness and longevity of the building to which the...
openaire +2 more sources
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Geological-economic evaluation of mineral resources (тopical issues, methodological aspects)
Мінеральні ресурси України, 2017 Author was shown the status of the geological study for the economic evaluation of mineral deposits in Ukraine. It is shown that most subsoil use objects require a geological and economic evaluation (GEE) or a re-evaluation in order to obtain objective ...
O. A. Lysenko
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Iron Keys Deposited in the Foundation of Glasgow Bridge
Proceedings of the Society of Antiquaries of ScotlandJohn Buchanan, a corresponding member of the Society, wrote to inform them of two large iron keys that were found deposited in the foundations of the ancient bridge of the River Clyde.
openaire +2 more sources
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
EVALUASI PENURUNAN TANAH LIAT DENGAN METODE SUB-LAYER
Civil Engineering Dimension, 2003 Consolidation settlement is commonly computed using one-point method, where a clay deposit is assumed as one layer and the stress increase from foundation is taken at the middle of the layer.
Sugeng Raharjo Condro +2 more
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