Results 241 to 250 of about 8,780,344 (351)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Development of a decision tree diagram for classifying study designs in tumour pathology research: a multidisciplinary approach. [PDF]

J Pathol Clin Res
Craciun OM, García-Ovejero E, Campbell F, Montes-Mota M, Holdenrieder S, Trulson I, Worf K, Gabriel S, Kowalewska M, Michalek I, Maslova K, Taraszkiewicz L, Del Águila J, Colling R, Tan PH, Goldman-Lévy G, Giesen C, Cierco Jimenez R, Lokuhetty D, Cree IA, Indave I, Pérez Gómez B, Chechlińska M, Pollán Santamaría M, Plans-Beriso E, WCT EVI MAP Project Team.   +25 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Sevoflurane Exposure Exacerbates Memory Impairment and Pathological Manifestation by Inhibiting AKT/mTOR-Mediated Autophagy in P301L Tau Transgenic Mice. [PDF]

CNS Neurosci Ther
He K, Zhang Z, Li Y, Xiong W, Xing Y, Gao W, Kong W, Chen L, Yang X, Dai Z.   +9 more
europepmc   +1 more source

Evidence-Based Policing as a Foundational Policing Model for the INP

Yobhel levic De fretes, Muhammad Krisna Bayunarendro, Hillary Cornelia   +2 more
openalex   +2 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Reply: Urgent Transcatheter Aortic Valve Replacement: Emerging Indication Needing Emergent Evidence. [PDF]

JACC Adv
Zhou JY, Stub D.
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Airway clearance techniques for adults receiving extracorporeal membrane oxygenation for severe acute respiratory failure: a scoping review protocol. [PDF]

BMJ Open
Lunn T, Swingwood E, Cochrane H, Walker S, Cramp F.   +4 more
europepmc   +1 more source

Mother tongue-based education in a diverse society and the acquisition of foundational skills: Evidence from the Philippines

Takiko Igarashi, Sandy Maulana, Daniel Suryadarma   +2 more
openalex   +1 more source