Results 61 to 70 of about 26,307 (269)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Study on the Stability of Buildings During Excavation in Urban Core Areas

Applied Sciences
Excavations in urban cores, in close proximity to existing structures, can significantly influence the structural loading. This study, based on a specific section of the foundation pit for the Yaoziqiu area road network project, constructs a mechanical ...
Kang Liu, Huafeng Liu, Yuntai Gao, Zijian Wang, Yunchuan Wang, Qi Liu, Chaolin Jia, Zihang Huang, Bin Zhang   +8 more
doaj   +1 more source

Effect of Depth of Embedment on Foundation Settlement

Soils and Foundations, 1984
ABSTRACT It is pointed out firstly that Fox’s method of computing the settlement of an embedded foundation is unsuitable because the solution given by Fox based on the superposition of Mindlin’s first solution does by no means conform to the stress state which can be visualized within the soil mass around a foundation. It can be concluded accordingly
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Application of vacuum preloading combining mixing pile method in treatment of tram foundation

Yantu gongcheng xuebao, 2017
Due to the green and environmental protection operation mode, the tram is leading the transportation industry into sustainable development in China. According to the structural characteristics and engineering properties of soft soil foundation in Nanjing,
ZHUANG Yan 1,3, WANG Xiao-dong 2, CHENG Jun 4
doaj   +1 more source

Elastic settlement of ring foundations

Soils and Foundations, 2015
AbstractIn this paper, numerical computations using the finite difference method are carried out in order to investigate the settlement of ring foundations resting over an elastic half space. The main goal of the present work is to introduce a closed form solution for calculating elastic settlement of ring foundations.
Naseri, Mojtaba, Hosseininia, Ehsan Seyedi   +1 more
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Settlement and deformation laws of new and old subgrades in reconstruction and extension of expressways

Yantu gongcheng xuebao
The differential settlement and settlement control of the new and old road foundations are the important problem faced by the reconstruction and expansion projects in soft soil areas.
LI Xingming 1, ZHU Xi 1, SHI Dequan 1, QIN Lei 1, WANG Caijin 2, 3, WANG Meng 3
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source